UMMS Affiliation

Program in Molecular Medicine; Division of Cardiovascular Medicine, Department of Medicine; Graduate School of Biomedical Sciences

Publication Date


Document Type



Biochemical Phenomena, Metabolism, and Nutrition | Cellular and Molecular Physiology | Exercise Physiology | Exercise Science | Genetic Phenomena | Molecular Biology | Nutritional and Metabolic Diseases | Pathological Conditions, Signs and Symptoms | Tissues


Exercise mitigates chronic diseases such as diabetes, cardiovascular diseases, and obesity; however, the molecular mechanisms governing protection from these diseases are not completely understood. Here we demonstrate that exercise rescues metabolically compromised high fat diet (HFD) fed mice, and reprograms subcutaneous white adipose tissue (scWAT). Using transcriptomic profiling, scWAT was analyzed for HFD gene expression changes that were rescued by exercise. Gene networks involved in vascularization were identified as prominent targets of exercise, which led us to investigate the vasculature architecture and endothelial phenotype. Vascular density in scWAT was found to be compromised in HFD, and exercise rescued this defect. Similarly, angiogenic capacity as measured by ex vivo capillary sprouting was significantly promoted with exercise. Together, these data demonstrate that exercise enhances scWAT vascularization and functional capacity for angiogenesis, and can prevent the detrimental effects of HFD. The improvement in these indices correlates with improvement of whole-body metabolism, suggesting that scWAT vascularization may be a potential therapeutic target for metabolic disease.


adipose tissue, angiogenesis, exercise, glucose homeostasis, high-fat diet, metabolism

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Copyright © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (

DOI of Published Version



Int J Mol Sci. 2019 Apr 25;20(8):2046. pii: ijms20082046. doi: 10.3390/ijms20082046. Link to article on publisher's site

Journal/Book/Conference Title

International journal of molecular sciences

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PubMed ID


Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.