UMMS Affiliation

Division of Infectious Diseases and Immunology, Department of Medicine

Publication Date


Document Type



Amino Acids, Peptides, and Proteins | Biochemistry | Immunology and Infectious Disease | Molecular Biology


Fruit flies elicit effective defense responses against numerous microbes. The responses against Gram-negative bacteria are mediated by the Imd pathway, an evolutionarily conserved NF-kappaB pathway recognizing meso-diaminopimelic acid (DAP)-type peptidoglycan from bacterial cell walls. Several reviews already provide a detailed view of ligand recognition and signal transduction during Imd signaling, but the formation and regulation of the signaling complex immediately downstream of the peptidoglycan-sensing receptors is still elusive. In this review, we focus on the formation of the Imd amyloidal signaling center and post-translational modifications in the assembly and disassembly of the Imd signaling complex.


Drosophila immunity, Functional amyloid, Imd signaling

Rights and Permissions

© 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (

DOI of Published Version



Insect Biochem Mol Biol. 2019 May;108:16-23. doi: 10.1016/j.ibmb.2019.03.003. Epub 2019 Mar 9. Link to article on publisher's site

Journal/Book/Conference Title

Insect biochemistry and molecular biology

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Link to Article in PubMed

PubMed ID


Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.