Division of Infectious Diseases and Immunology, Department of Medicine
Amino Acids, Peptides, and Proteins | Biochemistry | Immunology and Infectious Disease | Molecular Biology
Fruit flies elicit effective defense responses against numerous microbes. The responses against Gram-negative bacteria are mediated by the Imd pathway, an evolutionarily conserved NF-kappaB pathway recognizing meso-diaminopimelic acid (DAP)-type peptidoglycan from bacterial cell walls. Several reviews already provide a detailed view of ligand recognition and signal transduction during Imd signaling, but the formation and regulation of the signaling complex immediately downstream of the peptidoglycan-sensing receptors is still elusive. In this review, we focus on the formation of the Imd amyloidal signaling center and post-translational modifications in the assembly and disassembly of the Imd signaling complex.
Drosophila immunity, Functional amyloid, Imd signaling
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© 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
DOI of Published Version
Insect Biochem Mol Biol. 2019 May;108:16-23. doi: 10.1016/j.ibmb.2019.03.003. Epub 2019 Mar 9. Link to article on publisher's site
Insect biochemistry and molecular biology
Kleino, Anni and Silverman, Neal S., "Regulation of the Drosophila Imd pathway by signaling amyloids" (2019). Open Access Articles. 3792.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.