UMMS Affiliation
Division of Infectious Diseases and Immunology, Department of Medicine
Publication Date
2019-05-01
Document Type
Article
Disciplines
Amino Acids, Peptides, and Proteins | Biochemistry | Immunology and Infectious Disease | Molecular Biology
Abstract
Fruit flies elicit effective defense responses against numerous microbes. The responses against Gram-negative bacteria are mediated by the Imd pathway, an evolutionarily conserved NF-kappaB pathway recognizing meso-diaminopimelic acid (DAP)-type peptidoglycan from bacterial cell walls. Several reviews already provide a detailed view of ligand recognition and signal transduction during Imd signaling, but the formation and regulation of the signaling complex immediately downstream of the peptidoglycan-sensing receptors is still elusive. In this review, we focus on the formation of the Imd amyloidal signaling center and post-translational modifications in the assembly and disassembly of the Imd signaling complex.
Keywords
Drosophila immunity, Functional amyloid, Imd signaling
Rights and Permissions
© 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
DOI of Published Version
10.1016/j.ibmb.2019.03.003
Source
Insect Biochem Mol Biol. 2019 May;108:16-23. doi: 10.1016/j.ibmb.2019.03.003. Epub 2019 Mar 9. Link to article on publisher's site
Journal/Book/Conference Title
Insect biochemistry and molecular biology
Related Resources
PubMed ID
30857831
Repository Citation
Kleino, Anni and Silverman, Neal S., "Regulation of the Drosophila Imd pathway by signaling amyloids" (2019). Open Access Articles. 3792.
https://escholarship.umassmed.edu/oapubs/3792
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Included in
Amino Acids, Peptides, and Proteins Commons, Biochemistry Commons, Immunology and Infectious Disease Commons, Molecular Biology Commons