UMMS Affiliation
Department of Neurobiology
Publication Date
2019-02-01
Document Type
Article
Disciplines
Biochemical Phenomena, Metabolism, and Nutrition | Hemic and Lymphatic Diseases | Medical Pharmacology | Medicinal Chemistry and Pharmaceutics | Nutritional and Metabolic Diseases | Pharmacology
Abstract
Clozapine is an antipsychotic known for its superior efficacy in treating drug-resistant Schizophrenia. However, Clozapine induces various side effects such as hyperglycemia, agranulocytosis, weight gain etc. The mechanisms of these Clozapine-induced side effects have remained largely elusive though an important role is ascribed to 5-HT2A (Serotonin receptor subtype-2A). In this pilot study, we report for the first time that the 5-HT2A 'global' knockout mice (Htr2a(-/-)) are resistant to the Clozapine-induced hyperglycemia. Importantly though, the Htr2a(-/-) mice exhibit near normal basal glucose metabolism in the glucose tolerance tests. Collectively, the Htr2a(-/-) mice provide an important tool to study the Clozapine-induced hyperglycemia.
Keywords
5-HT(2A), Clozapine, Hyperglycemia
Rights and Permissions
© 2018 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
DOI of Published Version
10.1016/j.jphs.2018.11.015
Source
J Pharmacol Sci. 2019 Feb;139(2):133-135. doi: 10.1016/j.jphs.2018.11.015. Epub 2018 Dec 18. Link to article on publisher's site
Journal/Book/Conference Title
Journal of pharmacological sciences
Related Resources
PubMed ID
30600145
Repository Citation
Joshi, Radhika Sudhir; Singh, Shishu Pal; and Panicker, Mitradas M., "5-HT2A deletion protects against Clozapine-induced hyperglycemia" (2019). Open Access Articles. 3777.
https://escholarship.umassmed.edu/oapubs/3777
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Included in
Biochemical Phenomena, Metabolism, and Nutrition Commons, Hemic and Lymphatic Diseases Commons, Medical Pharmacology Commons, Medicinal Chemistry and Pharmaceutics Commons, Nutritional and Metabolic Diseases Commons, Pharmacology Commons