UMMS Affiliation

Department of Neurobiology

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Document Type



Biochemical Phenomena, Metabolism, and Nutrition | Hemic and Lymphatic Diseases | Medical Pharmacology | Medicinal Chemistry and Pharmaceutics | Nutritional and Metabolic Diseases | Pharmacology


Clozapine is an antipsychotic known for its superior efficacy in treating drug-resistant Schizophrenia. However, Clozapine induces various side effects such as hyperglycemia, agranulocytosis, weight gain etc. The mechanisms of these Clozapine-induced side effects have remained largely elusive though an important role is ascribed to 5-HT2A (Serotonin receptor subtype-2A). In this pilot study, we report for the first time that the 5-HT2A 'global' knockout mice (Htr2a(-/-)) are resistant to the Clozapine-induced hyperglycemia. Importantly though, the Htr2a(-/-) mice exhibit near normal basal glucose metabolism in the glucose tolerance tests. Collectively, the Htr2a(-/-) mice provide an important tool to study the Clozapine-induced hyperglycemia.


5-HT(2A), Clozapine, Hyperglycemia

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© 2018 The Authors. This is an open access article under the CC BY-NC-ND license (

DOI of Published Version



J Pharmacol Sci. 2019 Feb;139(2):133-135. doi: 10.1016/j.jphs.2018.11.015. Epub 2018 Dec 18. Link to article on publisher's site

Journal/Book/Conference Title

Journal of pharmacological sciences

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Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.