UMMS Affiliation

Program in Molecular Medicine

Publication Date

2019-02-01

Document Type

Article

Disciplines

Amino Acids, Peptides, and Proteins | Animal Experimentation and Research | Hemic and Immune Systems | Immunology of Infectious Disease | Nervous System | Virology | Viruses

Abstract

Macrophage (mac)-tropic human immnunodeficiency virus type 1 (HIV-1) and simian immnunodeficiency virus (SIV) in brain are associated with neurological disease. Mac-tropic HIV-1 evolves enhanced CD4 interactions that enable macrophage infection via CD4, which is in low abundance. In contrast, mac-tropic SIV is associated with CD4-independent infection via direct CCR5 binding. Recently, mac-tropic simian-human immunodeficiency virus (SHIV) from macaque brain was also reported to infect cells via CCR5 without CD4. Since SHIV envelope proteins (Envs) are derived from HIV-1, we tested more than 100 HIV-1 clade B Envs for infection of CD4-negative, CCR5(+) Cf2Th/CCR5 cells. However, no infection was detected. Our data suggest that there are differences in the evolution of mac-tropism in SIV and SHIV compared to HIV-1 clade B due to enhanced interactions with CCR5 and CD4, respectively.

Rights and Permissions

© The Author(s) 2018. Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

DOI of Published Version

10.1007/s00705-018-4094-1

Source

Arch Virol. 2019 Feb;164(2):473-482. doi: 10.1007/s00705-018-4094-1. Epub 2018 Nov 10. Link to article on publisher's site

Journal/Book/Conference Title

Archives of virology

Related Resources

Link to Article in PubMed

PubMed ID

30415390

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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