Department of Pathology; Graduate School of Biomedical Sciences, Program in Immunology and Microbiology
Digestive System | Enzymes and Coenzymes | Hemic and Immune Systems | Immunity | Immunopathology | Medical Immunology | Tissues
Innate lymphoid cells (ILC) are lymphocytes that lack an antigen-specific receptor and are preferentially localized in non-lymphoid tissues, such as mucosal barriers. In these locations ILC respond to tissue perturbations by producing factors that promote tissue repair and improve barrier integrity. We show that mice lacking the Tec kinase ITK have impaired intestinal tissue integrity, and a reduced ability to restore homeostasis after tissue damage. This defect is associated with a substantial loss of Type 2 ILC (ILC2) in the intestinal lamina propria. Adoptive transfer of bone marrow ILC2 precursors confirms a cell-intrinsic role for ITK. Intestinal ILC2 numbers in Itk(-/-) mice are restored by the administration of IL-2 complexes, also leading to improved intestinal tissue damage repair. Reduced Bcl-2 expression in intestinal Itk(-/-) ILC2 is also restored to WT levels after IL-2 complex treatment, indicating a tissue-specific role for ITK in ILC2 survival in the intestine.
Innate lymphoid cells, Mucosal immunology
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DOI of Published Version
Nat Commun. 2019 Feb 15;10(1):784. doi: 10.1038/s41467-019-08699-9. Link to article on publisher's site
Cho H, Reboldi A, Hall JA, Berg LJ. (2019). The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine. Open Access Articles. https://doi.org/10.1038/s41467-019-08699-9. Retrieved from https://escholarship.umassmed.edu/oapubs/3757
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This work is licensed under a Creative Commons Attribution 4.0 License.