UMMS Affiliation
Program in Innate Immunity; Department of Medicine, Division of Infectious Diseases and Immunology
Publication Date
2019-1
Document Type
Article
Disciplines
Cell Biology | Cellular and Molecular Physiology | Hemic and Immune Systems | Immunity | Immunopathology
Abstract
Interferons (IFNs) are critical determinants in immune-competence and autoimmunity, and are endogenously regulated by a low-level constitutive feedback loop. However, little is known about the functions and origins of constitutive IFN. Recently, lipopolysaccharide (LPS)-induced IFN was implicated as a driver of necroptosis, a necrotic form of cell death downstream of receptor-interacting protein (RIP) kinase activation and executed by mixed lineage kinase like-domain (MLKL) protein. We found that the pre-established IFN status of the cell, instead of LPS-induced IFN, is critical for the early initiation of necroptosis in macrophages. This pre-established IFN signature stems from cytosolic DNA sensing via cGAS/STING, and maintains the expression of MLKL and one or more unknown effectors above a critical threshold to allow for MLKL oligomerization and cell death. Finally, we found that elevated IFN-signaling in systemic lupus erythematosus (SLE) augments necroptosis, providing a link between pathological IFN and tissue damage during autoimmunity.
Rights and Permissions
Copyright © ADMC Associazione Differenziamento e Morte Cellulare 2018. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
DOI of Published Version
10.1038/s41418-018-0122-7
Source
Cell Death Differ. 2019 Jan;26(2):332-347. doi: 10.1038/s41418-018-0122-7. Epub 2018 May 21. Link to article on publisher's site
Journal/Book/Conference Title
Cell death and differentiation
Related Resources
PubMed ID
29786074
Repository Citation
Sarhan, Joseph; Liu, Beiyun C.; Muendlein, Hayley I.; Weindel, Chi G.; Smirnova, Irina; Tang, Amy Y.; Ilyukha, Vladimir; Sorokin, Maxim; Buzdin, Anton; Fitzgerald, Katherine A.; and Poltorak, Alexander, "Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis" (2019). Open Access Articles. 3745.
https://escholarship.umassmed.edu/oapubs/3745
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Included in
Cell Biology Commons, Cellular and Molecular Physiology Commons, Hemic and Immune Systems Commons, Immunity Commons, Immunopathology Commons