UMMS Affiliation

Department of Microbiology and Physiological Systems; Department of Molecular, Cell and Cancer Biology; Program in Molecular Medicine

Publication Date

2019-02-22

Document Type

Article

Disciplines

Amino Acids, Peptides, and Proteins | Biological Factors | Cell Biology | Congenital, Hereditary, and Neonatal Diseases and Abnormalities | Immunology and Infectious Disease | Virology | Virus Diseases | Viruses

Abstract

Congenital microcephaly occurs in utero during Zika virus (ZIKV) infection. The single-gene disorder, Majewski osteodysplastic primordial dwarfism type II (MOPDII), also leads to microcephaly and is concomitant with a decrease in the centrosomal protein, pericentrin (PCNT). This protein is a known contributor of mitotic spindle misorientation and ultimately, microcephaly. Similar to MOPDII, either viral infection or interferon (IFN)-alpha exposure reduced PCNT levels at the mitotic spindle poles. We unexpectedly found that infection of cells with any one of a diverse set of viruses, such as ZIKV, dengue virus, cytomegalovirus, influenza A virus, or hepatitis B virus, or treatment of cells with the anti-viral cytokine, IFN-alpha, produced mitotic spindle misorientation. These findings demonstrate a related mechanism for the development of microcephaly in viral infection, the host's antiviral IFN response, and primordial dwarfism.

Keywords

Biological Sciences, Cell Biology, Pathophysiology, Virology

Rights and Permissions

Copyright 2019 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

DOI of Published Version

10.1016/j.isci.2019.01.025

Source

iScience. 2019 Feb 22;12:270-279. doi: 10.1016/j.isci.2019.01.025. Epub 2019 Jan 21. Link to article on publisher's site

Journal/Book/Conference Title

iScience

Related Resources

Link to Article in PubMed

PubMed ID

30716700

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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