Department of Medicine, Division of Gastroenterology
Digestive System Diseases | Gastroenterology | Hepatology
Extracellular vesicles (EVs) are small and heterogeneous membrane-bound structures released by cells and found in all biological fluids. They are effective intercellular communicators, acting on a number of close and/or distant target cells. EV cargo may reflect the cell of origin as well as the specific stress that induces their formation and release. They transport a variety of bioactive molecules, including messenger RNA, noncoding RNAs, proteins, lipids, and metabolites, that can be transferred among cells, regulating various cell responses. Alteration in the concentration and composition of EVs in biological fluids is a typical hallmark of pathologies in different liver diseases. Circulating EVs can serve as biomarkers or as messengers following uptake by other cells. This review is a meeting report from the International Liver Congress 2018 (European Association for the Study of the Liver) celebrated in Paris (Symposium: Extracellular vesicles and signal transmission) that discusses the role of EVs in several liver diseases, highlighting their potential value as disease biomarkers and therapeutic opportunities.
extracellular vesicles, disease biomarkers, liver diseases
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© 2018 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
DOI of Published Version
Hepatol Commun. 2019 Jan 2;3(2):305-315. doi: 10.1002/hep4.1300. eCollection 2019 Feb. Link to article on publisher's site
Banales, Jesus M.; Feldstein, Ariel E.; Sanger, Hanna; Lukacs-Kornek, Veronika; Szabo, Gyongyi; and Kornek, Miroslaw, "Extracellular Vesicles in Liver Diseases: Meeting Report from the International Liver Congress 2018" (2019). Open Access Articles. 3729.
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This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.