UMMS Affiliation

Department of Medicine, Division of Hematology Oncology

Publication Date


Document Type

Article Postprint


Health Services Administration | Hematology | Hemic and Lymphatic Diseases | Neoplasms | Oncology | Psychiatry and Psychology


Survivorship care plans may facilitate long-term care for cancer survivors, but their effectiveness has not been established in hematopoietic cell transplantation recipients. We evaluated the impact of individualized survivorship care plans on patient-reported outcomes among transplant survivors. Adult (>/=18 years at transplant) survivors who were 1-5 years post-transplantation, proficient in English, and without relapse or secondary cancers were eligible for this multicenter randomized trial. Care plans were developed based on risk-factors and treatment exposures using patient data routinely submitted by transplant centers to the Center for International Blood and Marrow Transplant Research and published guidelines for long-term follow-up of transplant survivors. Phone surveys assessing patient-reported outcomes were conducted at baseline and 6-months. Primary endpoint was confidence in survivorship information, and secondary endpoints included cancer and treatment distress, knowledge of transplant exposures, health care utilization and health-related quality of life. Of 495 patients enrolled, 458 completed a baseline survey and were randomized (care plan=231, standard care=227); 200 (87%) and 199 (88%) completed the 6-month assessments, respectively. Patient characteristics were balanced in the two arms. Participants on care plan arm reported significantly lower distress scores at 6-months and an increase in the Mental Component Summary quality of life score assessed by the SF12 instrument. No effect was observed on the endpoint of confidence in survivorship information or other secondary outcomes. Provision of individualized survivorship care plans generated using registry data was associated with reduced distress and improved mental domain of quality of life among 1-5 year hematopoietic cell transplantation survivors. ( NCT02200133).


Late complications, Quality of Life, Stem Cell Transplantation, Survivorship, Survivorship care plan

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Copyright © 2018, Ferrata Storti Foundation. Accepted manuscript published as allowed by publisher's open access policy at

DOI of Published Version



Haematologica. 2018 Dec 4. pii: haematol.2018.203919. doi: 10.3324/haematol.2018.203919. [Epub ahead of print] Link to article on publisher's site

Journal/Book/Conference Title



Full author list omitted for brevity. For the full list of authors, see article.

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