UMMS Affiliation
RNA Therapeutics Institute
Publication Date
2018-11-06
Document Type
Article
Disciplines
Biochemistry | Biology | Chemistry | Nucleic Acids, Nucleotides, and Nucleosides
Abstract
Understanding how life began is one of the most fascinating problems to solve. By approaching this enigma from a chemistry perspective, the goal is to define what series of chemical reactions could lead to the synthesis of nucleotides, amino acids, lipids, and other cellular components from simple feedstocks under prebiotically plausible conditions. It is well established that evolution of life involved RNA which plays central roles in both inheritance and catalysis. In this review, we present historically important and recently published articles aimed at understanding the emergence of RNA nucleosides and nucleotides on the early Earth.
Keywords
nucleotide and nucleoside synthesis, origin of life, prebiotic chemistry
Rights and Permissions
© 2018 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
DOI of Published Version
10.3390/life8040057
Source
Life (Basel). 2018 Nov 6;8(4). pii: life8040057. doi: 10.3390/life8040057. Link to article on publisher's site
Journal/Book/Conference Title
Life (Basel, Switzerland)
Related Resources
PubMed ID
30404133
Repository Citation
Biscans A. (2018). Exploring the Emergence of RNA Nucleosides and Nucleotides on the Early Earth. Open Access Articles. https://doi.org/10.3390/life8040057. Retrieved from https://escholarship.umassmed.edu/oapubs/3673
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Included in
Biochemistry Commons, Biology Commons, Chemistry Commons, Nucleic Acids, Nucleotides, and Nucleosides Commons