UMMS Affiliation

RNA Therapeutics Institute

Publication Date


Document Type



Biochemistry | Biology | Chemistry | Nucleic Acids, Nucleotides, and Nucleosides


Understanding how life began is one of the most fascinating problems to solve. By approaching this enigma from a chemistry perspective, the goal is to define what series of chemical reactions could lead to the synthesis of nucleotides, amino acids, lipids, and other cellular components from simple feedstocks under prebiotically plausible conditions. It is well established that evolution of life involved RNA which plays central roles in both inheritance and catalysis. In this review, we present historically important and recently published articles aimed at understanding the emergence of RNA nucleosides and nucleotides on the early Earth.


nucleotide and nucleoside synthesis, origin of life, prebiotic chemistry

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© 2018 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (

DOI of Published Version



Life (Basel). 2018 Nov 6;8(4). pii: life8040057. doi: 10.3390/life8040057. Link to article on publisher's site

Journal/Book/Conference Title

Life (Basel, Switzerland)

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Link to Article in PubMed

PubMed ID


Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.