Title
Signaling Pathways Induced by Leptin during Epithelial(-)Mesenchymal Transition in Breast Cancer
UMMS Affiliation
Department of Biochemistry and Molecular Pharmacology
Publication Date
2018-11-06
Document Type
Article
Disciplines
Amino Acids, Peptides, and Proteins | Biological Factors | Cancer Biology | Cells | Hormones, Hormone Substitutes, and Hormone Antagonists | Molecular Biology | Neoplasms
Abstract
Leptin is an adipokine that is overexpressed in obese and overweight people. Interestingly, women with breast cancer present high levels of leptin and of its receptor ObR. Leptin plays an important role in breast cancer progression due to the biological processes it participates in, such as epithelial(-)mesenchymal transition (EMT). EMT consists of a series of orchestrated events in which cell(-)cell and cell(-)extracellular matrix interactions are altered and lead to the release of epithelial cells from the surrounding tissue. The cytoskeleton is also re-arranged, allowing the three-dimensional movement of epithelial cells into the extracellular matrix. This transition provides cells with the ability to migrate and invade adjacent or distal tissues, which is a classic feature of invasive or metastatic carcinoma cells. In recent years, the number of cases of breast cancer has increased, making this disease a public health problem worldwide and the leading cause of death due to cancer in women. In this review, we focus on recent advances that establish: (1) leptin as a risk factor for the development of breast cancer, and (2) leptin as an inducer of EMT, an event that promotes tumor progression.
Keywords
EMT, breast cancer, leptin, transcription factors
Rights and Permissions
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
DOI of Published Version
10.3390/ijms19113493
Source
Int J Mol Sci. 2018 Nov 6;19(11). pii: ijms19113493. doi: 10.3390/ijms19113493. Link to article on publisher's site
Journal/Book/Conference Title
International journal of molecular sciences
Related Resources
PubMed ID
30404206
Repository Citation
Olea-Flores, Monserrat; Juarez-Cruz, Juan Carlos; Mendoza-Catalan, Miguel A.; Padilla-Benavides, Teresita; and Navarro-Tito, Napoleon, "Signaling Pathways Induced by Leptin during Epithelial(-)Mesenchymal Transition in Breast Cancer" (2018). Open Access Articles. 3670.
https://escholarship.umassmed.edu/oapubs/3670
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Included in
Amino Acids, Peptides, and Proteins Commons, Biological Factors Commons, Cancer Biology Commons, Cells Commons, Hormones, Hormone Substitutes, and Hormone Antagonists Commons, Molecular Biology Commons, Neoplasms Commons