UMMS Affiliation

Department of Molecular, Cell and Cancer Biology

Publication Date

2018-11-07

Document Type

Article

Disciplines

Cancer Biology | Cell Biology | Cells | Digestive System Diseases | Gastroenterology | Hemic and Immune Systems | Hepatology | Neoplasms

Abstract

Colon cancer is still one of the most common causes of cancer in human and is characterized by lymphocyte infiltrates and originates from the epithelial cells found in the lining of colon or rectum of the gastrointestinal tract. Mesenchymal stem cells (MSCs) are composed of the multipotent stem cell group of stroma and can be differentiated as various cell lineages, such as fibroblasts, osteoblasts, and adipocytes. MSCs provide mechanical and structural support and have potential functions during tumor growth and metastasis. The efficacy of MSC-based therapies is partly dependent on the migration and homing of MSCs to tumors and metastatic sites. However, their migratory and engraftment potential is poorly understood. In this review, the characteristics and mechanisms of MSC's dynamic interaction with colon cancer were summarized, particularly the potential functions of MSCs on colon cancer, including its role in improving tumor growth and as a potential candidate for tumor therapy. Understanding MSC homing provides new insights into the manipulation of MSC and the improvement of their efficacy for colon cancer therapy.

Keywords

Mesenchymal Stem Cells, Colorectal Cancer

Rights and Permissions

Copyright © 2018 Shan Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

DOI of Published Version

10.1155/2018/7628763

Source

Can J Gastroenterol Hepatol. 2018 Nov 7;2018:7628763. doi: 10.1155/2018/7628763. eCollection 2018. Link to article on publisher's site

Journal/Book/Conference Title

Canadian journal of gastroenterology and hepatology

Related Resources

Link to Article in PubMed

PubMed ID

30533404

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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