UMass Chan Affiliations
Department of Molecular, Cell and Cancer BiologyDocument Type
Journal ArticlePublication Date
2018-11-07Keywords
Mesenchymal Stem CellsColorectal Cancer
Cancer Biology
Cell Biology
Cells
Digestive System Diseases
Gastroenterology
Hemic and Immune Systems
Hepatology
Neoplasms
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Show full item recordAbstract
Colon cancer is still one of the most common causes of cancer in human and is characterized by lymphocyte infiltrates and originates from the epithelial cells found in the lining of colon or rectum of the gastrointestinal tract. Mesenchymal stem cells (MSCs) are composed of the multipotent stem cell group of stroma and can be differentiated as various cell lineages, such as fibroblasts, osteoblasts, and adipocytes. MSCs provide mechanical and structural support and have potential functions during tumor growth and metastasis. The efficacy of MSC-based therapies is partly dependent on the migration and homing of MSCs to tumors and metastatic sites. However, their migratory and engraftment potential is poorly understood. In this review, the characteristics and mechanisms of MSC's dynamic interaction with colon cancer were summarized, particularly the potential functions of MSCs on colon cancer, including its role in improving tumor growth and as a potential candidate for tumor therapy. Understanding MSC homing provides new insights into the manipulation of MSC and the improvement of their efficacy for colon cancer therapy.Source
Can J Gastroenterol Hepatol. 2018 Nov 7;2018:7628763. doi: 10.1155/2018/7628763. eCollection 2018. Link to article on publisher's site
DOI
10.1155/2018/7628763Permanent Link to this Item
http://hdl.handle.net/20.500.14038/40857PubMed ID
30533404Related Resources
Rights
Copyright © 2018 Shan Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Distribution License
http://creativecommons.org/licenses/by/4.0/ae974a485f413a2113503eed53cd6c53
10.1155/2018/7628763
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Except where otherwise noted, this item's license is described as Copyright © 2018 Shan Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.