Department of Neurobiology
Cell and Developmental Biology | Developmental Neuroscience | Nervous System
Wnt ligands are secreted glycoproteins that control many developmental processes and are crucial for homeostasis of numerous tissues in the adult organism. Signal transduction of Wnts involves the binding of Wnts to receptor complexes at the surface of target cells. These receptor complexes are commonly formed between a member of the Frizzled family of seven-pass transmembrane proteins and a co-receptor, which is usually a single-pass transmembrane protein. Among these co-receptors are several with structural homology to receptor tyrosine kinases, including Ror, PTK7, Ryk and MUSK. In vertebrates, Ror-2 and PTK7 are important regulators of planar cell polarity (PCP). By contrast, PCP phenotypes were not reported for mutations in off-track (otk) and off-track2 (otk2), encoding the Drosophila orthologs of PTK7. Here we show that Drosophila Ror is expressed in the nervous system and localizes to the plasma membrane of perikarya and neurites. A null allele of Ror is homozygous viable and fertile, does not display PCP phenotypes and interacts genetically with mutations in otk and otk2 We show that Ror binds specifically to Wingless (Wg), Wnt4 and Wnt5 and also to Frizzled2 (Fz2) and Otk. Our findings establish Drosophila Ror as a Wnt co-receptor expressed in the nervous system.
Nervous system development, Planar cell polarity, Ror, Wnt signaling
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Copyright © 2018. Published by The Company of Biologists Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
DOI of Published Version
Biol Open. 2018 Nov 2;7(11). pii: bio.033001. doi: 10.1242/bio.033001. Link to article on publisher's site
Ripp C, Loth J, Petrova I, Linnemannstons K, Ulepic M, Fradkin LG, Noordermeer J, Wodarz A. (2018). Drosophila Ror is a nervous system-specific co-receptor for Wnt ligands. Open Access Publications by UMass Chan Authors. https://doi.org/10.1242/bio.033001. Retrieved from https://escholarship.umassmed.edu/oapubs/3660
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This work is licensed under a Creative Commons Attribution 3.0 License.