UMMS Affiliation

Department of Medicine

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Document Type



Bacterial Infections and Mycoses | Diagnosis | Infectious Disease | Pathological Conditions, Signs and Symptoms | Respiratory Tract Diseases | Therapeutics


Staphylococcus simulans is a coagulase-negative organism, mainly an animal pathogen. Reports of human infection have been infrequent, mainly in patients with repeated animal contact. We report the first case of pleural empyema in an elderly woman. S. simulans tends to cause more severe infection because of a biofilm layer which helps in adherence and colonization of smooth surfaces, especially prosthetic devices, shunts, and catheters. The challenging problem even after CoNS isolation and identification is the assessment of their clinical relevance. Major factors that inhibit the penetration of antibiotics is the large-sized effusions/empyema, thickness of pleura, and the nature of antibiotic itself. Source control for septic patients remains the cornerstone of treatment along with optimal antimicrobial coverage. Staphylococcus simulans, a coagulase-negative staphylococcus, is emerging as an important cause of virulent infections with high mortality in humans. Given its propensity for multidrug resistance, including vancomycin, there is an imperative for early and accurate identification of the isolate. Despite aggressive treatment, the patient succumbed to her illness.


pleural empyema, bacterial infection, Staphylococcus simulans

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Copyright © 2018 Amos Lal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

DOI of Published Version



Case Rep Infect Dis. 2018 Oct 11;2018:7831284. doi: 10.1155/2018/7831284. eCollection 2018. Link to article on publisher's site

Journal/Book/Conference Title

Case reports in infectious diseases

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Link to Article in PubMed

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Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.