UMMS Affiliation

Department of Internal Medicine; Department of Medicine, Division of Hematology Oncology; Department of Pathology

Publication Date

2018-10-19

Document Type

Letter to the Editor

Disciplines

Amino Acids, Peptides, and Proteins | Cancer Biology | Cell Biology | Enzymes and Coenzymes | Genetic Phenomena | Genetics and Genomics | Hematology | Hemic and Lymphatic Diseases | Molecular Biology | Neoplasms | Oncology

Abstract

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia recognizes a distinct class of myeloid and lymphoid tumors with eosinophilia-related proliferations associated with specific gene rearrangements, one of which involves rearrangements of platelet-derived growth factor receptor B (PDGFRB) gene. We report a case of a rare PDGFRB rearrangement with SPTNB1 (spectrin beta, nonerythrocytic 1) that presented as atypical myeloproliferative neoplasm.

Keywords

Myeloproliferative neoplasm, PDGFR mutation

Rights and Permissions

© The Author(s). 2018 Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

DOI of Published Version

10.1186/s13039-018-0405-1

Source

Mol Cytogenet. 2018 Oct 19;11:56. doi: 10.1186/s13039-018-0405-1. eCollection 2018. Link to article on publisher's site

Journal/Book/Conference Title

Molecular cytogenetics

Related Resources

Link to Article in PubMed

PubMed ID

30377450

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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