UMMS Affiliation
Department of Internal Medicine; Department of Medicine, Division of Hematology Oncology; Department of Pathology
Publication Date
2018-10-19
Document Type
Letter to the Editor
Disciplines
Amino Acids, Peptides, and Proteins | Cancer Biology | Cell Biology | Enzymes and Coenzymes | Genetic Phenomena | Genetics and Genomics | Hematology | Hemic and Lymphatic Diseases | Molecular Biology | Neoplasms | Oncology
Abstract
The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia recognizes a distinct class of myeloid and lymphoid tumors with eosinophilia-related proliferations associated with specific gene rearrangements, one of which involves rearrangements of platelet-derived growth factor receptor B (PDGFRB) gene. We report a case of a rare PDGFRB rearrangement with SPTNB1 (spectrin beta, nonerythrocytic 1) that presented as atypical myeloproliferative neoplasm.
Keywords
Myeloproliferative neoplasm, PDGFR mutation
Rights and Permissions
© The Author(s). 2018 Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
DOI of Published Version
10.1186/s13039-018-0405-1
Source
Mol Cytogenet. 2018 Oct 19;11:56. doi: 10.1186/s13039-018-0405-1. eCollection 2018. Link to article on publisher's site
Journal/Book/Conference Title
Molecular cytogenetics
Related Resources
PubMed ID
30377450
Repository Citation
Furtado, Vanessa Fiorini; Saini, Neeraj Y.; Walsh, William V.; Bathini, Venu G.; and Miron, Patricia M., "Rare gene fusion rearrangement SPTNB1-PDGFRB in an atypical myeloproliferative neoplasm" (2018). Open Access Articles. 3643.
https://escholarship.umassmed.edu/oapubs/3643
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Included in
Amino Acids, Peptides, and Proteins Commons, Cancer Biology Commons, Cell Biology Commons, Enzymes and Coenzymes Commons, Genetic Phenomena Commons, Genetics and Genomics Commons, Hematology Commons, Hemic and Lymphatic Diseases Commons, Molecular Biology Commons, Neoplasms Commons, Oncology Commons