UMMS Affiliation

Department of Internal Medicine; Department of Medicine, Division of Hematology Oncology; Department of Pathology

Publication Date


Document Type

Letter to the Editor


Amino Acids, Peptides, and Proteins | Cancer Biology | Cell Biology | Enzymes and Coenzymes | Genetic Phenomena | Genetics and Genomics | Hematology | Hemic and Lymphatic Diseases | Molecular Biology | Neoplasms | Oncology


The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia recognizes a distinct class of myeloid and lymphoid tumors with eosinophilia-related proliferations associated with specific gene rearrangements, one of which involves rearrangements of platelet-derived growth factor receptor B (PDGFRB) gene. We report a case of a rare PDGFRB rearrangement with SPTNB1 (spectrin beta, nonerythrocytic 1) that presented as atypical myeloproliferative neoplasm.


Myeloproliferative neoplasm, PDGFR mutation

Rights and Permissions

© The Author(s). 2018 Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

DOI of Published Version



Mol Cytogenet. 2018 Oct 19;11:56. doi: 10.1186/s13039-018-0405-1. eCollection 2018. Link to article on publisher's site

Journal/Book/Conference Title

Molecular cytogenetics

Related Resources

Link to Article in PubMed

PubMed ID


Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.