Department of Internal Medicine; Department of Medicine, Division of Hematology Oncology; Department of Pathology
Letter to the Editor
Amino Acids, Peptides, and Proteins | Cancer Biology | Cell Biology | Enzymes and Coenzymes | Genetic Phenomena | Genetics and Genomics | Hematology | Hemic and Lymphatic Diseases | Molecular Biology | Neoplasms | Oncology
The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia recognizes a distinct class of myeloid and lymphoid tumors with eosinophilia-related proliferations associated with specific gene rearrangements, one of which involves rearrangements of platelet-derived growth factor receptor B (PDGFRB) gene. We report a case of a rare PDGFRB rearrangement with SPTNB1 (spectrin beta, nonerythrocytic 1) that presented as atypical myeloproliferative neoplasm.
Myeloproliferative neoplasm, PDGFR mutation
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© The Author(s). 2018 Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
DOI of Published Version
Mol Cytogenet. 2018 Oct 19;11:56. doi: 10.1186/s13039-018-0405-1. eCollection 2018. Link to article on publisher's site
Furtado VF, Saini NY, Walsh WV, Bathini VG, Miron PM. (2018). Rare gene fusion rearrangement SPTNB1-PDGFRB in an atypical myeloproliferative neoplasm. Open Access Publications by UMMS Authors. https://doi.org/10.1186/s13039-018-0405-1. Retrieved from https://escholarship.umassmed.edu/oapubs/3643
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This work is licensed under a Creative Commons Attribution 4.0 License.
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