Department of Microbiology and Physiological Systems
Bacterial Infections and Mycoses | Immunology of Infectious Disease | Immunopathology
Our understanding of the host response to infections has historically focused on "resistance" mechanisms that directly control pathogen replication. However, both pathogen effectors and antimicrobial immune pathways have the capacity to damage host tissue, and the ability to tolerate these insults can also be critical for host survival. These "tolerance" mechanisms may be equally as important as resistance to prevent disease in the context of a persistent infection, such as tuberculosis, when resistance mechanisms are ineffective and the pathogen persists in the tissue for long periods. Host tolerance encompasses a wide range of strategies, many of which involve regulation of the inflammatory response. Here we will examine general strategies used by macrophages and T cells to promote tolerance in the context of tuberculosis, and focus on pathways, such as regulation of inflammasome activation, that are emerging as common mediators of tolerance.
Mycobaterium tuberculosis, immunometabolism, inflammasome, persistent infections, tolerance
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Copyright © 2018 Olive and Sassetti. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
DOI of Published Version
Front Immunol. 2018 Sep 12;9:2094. doi: 10.3389/fimmu.2018.02094. eCollection 2018. Link to article on publisher's site
Frontiers in immunology
Olive, Andrew J. and Sassetti, Christopher M., "Tolerating the Unwelcome Guest; How the Host Withstands Persistent Mycobacterium tuberculosis" (2018). Open Access Articles. 3623.
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This work is licensed under a Creative Commons Attribution 4.0 License.