Disrupted asymmetry of inter- and intra-hemispheric functional connectivity in patients with drug-naive, first-episode schizophrenia and their unaffected siblings
Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
Authors
Zhu, FurongLiu, Feng
Guo, Wenbin
Chen, Jindong
Su, Qinji
Zhang, Zhikun
Li, Huabing
Fan, Xiaoduo
Zhao, Jingping
UMass Chan Affiliations
Department of PsychiatryDocument Type
Journal ArticlePublication Date
2018-10-01Keywords
AsymmetryEndophenotype
Functional connectivity
Olanzapine
Schizophrenia
Mental Disorders
Nervous System
Neuroscience and Neurobiology
Psychiatry
Metadata
Show full item recordAbstract
BACKGROUND: Lack of normal asymmetry in the brain has been reported in patients with schizophrenia. However, it remains unclear whether disrupted asymmetry originates from inter-hemispheric functional connectivity (FC) and/or intra-hemispheric FC in this patient population. METHODS: Forty-four patients with drug-naive, first-episode schizophrenia, 42 unaffected siblings, and 44 healthy controls underwent resting-state functional magnetic resonance imaging (fMRI) scan. The parameter of asymmetry (PAS) and support vector machine (SVM) were used to analyze the data. Patients were treated with olanzapine for 8 weeks. FINDINGS: Compared with healthy controls, patients showed lower PAS scores in the left middle temporal gyrus (MTG)/inferior temporal gyrus (ITG), left posterior cingulate cortex (PCC)/precuneus and left angular gyrus, and higher PAS scores in the left precentral gyrus/postcentral gyrus. Unaffected siblings also showed lower PAS scores in the left MTG/ITG and left PCC/precuneus relative to healthy controls. Further, SVM analysis showed that a combination of the PAS scores in these two clusters in patients at baseline was able to predict clinical response after 8weeks of olanzapine treatment with 77.27% sensitivity, 72.73% specificity, and 75.00% accuracy. INTERPRETATION: The present study suggests disrupted asymmetry of inter- and intra-hemispheric FC in drug-naive, first-episode schizophrenia; in addition, a reduced asymmetry of inter-hemispheric FC in the left MTG/ITG and left PCC/precuneus may serve as an endophenotype for schizophrenia, and may have clinical utility to predict response to olanzapine treatment. FUND: The National Key RandD Program of China and the National Natural Science Foundation of China.Source
EBioMedicine. 2018 Oct;36:429-435. doi: 10.1016/j.ebiom.2018.09.012. Epub 2018 Sep 18. Link to article on publisher's site
DOI
10.1016/j.ebiom.2018.09.012Permanent Link to this Item
http://hdl.handle.net/20.500.14038/40811PubMed ID
30241918Related Resources
Rights
©2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Distribution License
http://creativecommons.org/licenses/by-nc-nd/4.0/ae974a485f413a2113503eed53cd6c53
10.1016/j.ebiom.2018.09.012
Scopus Count
Collections
Except where otherwise noted, this item's license is described as ©2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).