Multi-ethnic genome-wide association study for atrial fibrillation
UMass Chan Affiliations
Department of Medicine, Division of Cardiovascular MedicineDocument Type
Journal ArticlePublication Date
2018-09-01Keywords
Atrial fibrillationmeta-analysis
genome-wide association studies
genes
Cardiology
Cardiovascular Diseases
Genetic Phenomena
Genetics and Genomics
Therapeutics
Metadata
Show full item recordAbstract
Atrial fibrillation (AF) affects more than 33 million individuals worldwide(1) and has a complex heritability(2). We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identified loci implicate genes enriched within cardiac developmental, electrophysiological, contractile and structural pathways. These results extend our understanding of the biological pathways underlying AF and may facilitate the development of therapeutics for AF.Source
Nat Genet. 2018 Sep;50(9):1225-1233. doi: 10.1038/s41588-018-0133-9. Epub 2018 Jun 11. Link to article on publisher's site
DOI
10.1038/s41588-018-0133-9Permanent Link to this Item
http://hdl.handle.net/20.500.14038/40798PubMed ID
29892015Notes
Full author list omitted for brevity. For the full list of authors, see article.
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10.1038/s41588-018-0133-9