Department of Biochemistry and Molecular Pharmacology; Department of Neurobiology
Cell Biology | Cells | Developmental Biology | Molecular Biology
Zinc transporters facilitate metal mobilization and compartmentalization, playing a key role in cellular development. Little is known about the mechanisms and pathways of Zn movement between Zn transporters and metalloproteins during myoblast differentiation. We analyzed the differential expression of ZIP and ZnT transporters during C2C12 myoblast differentiation. Zn transporters account for a transient decrease of intracellular Zn upon myogenesis induction followed by a gradual increase of Zn in myotubes. Considering the subcellular localization and function of each of the Zn transporters, our findings indicate that a fine regulation is necessary to maintain correct metal concentrations in the cytosol and subcellular compartments to avoid toxicity, maintain homeostasis, and for loading metalloproteins needed during myogenesis. This study advances our basic understanding of the complex Zn transport network during muscle differentiation.
Gene Expression, Myogenesis, Zinc, Zn content, Zn-transporters
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© 2018 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
DOI of Published Version
J Trace Elem Med Biol. 2018 Sep;49:27-34. doi: 10.1016/j.jtemb.2018.04.024. Epub 2018 Apr 25. Link to article on publisher's site
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
Paskavitz AL, Quintana J, Cangussu D, Tavera-Montanez C, Xiao Y, Ortiz-Mirnada S, Navea JG, Padilla-Benavides T. (2018). Differential expression of zinc transporters accompanies the differentiation of C2C12 myoblasts. Open Access Articles. https://doi.org/10.1016/j.jtemb.2018.04.024. Retrieved from https://escholarship.umassmed.edu/oapubs/3605
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