UMMS Affiliation

Department of Medicine

Publication Date

2018-10-15

Document Type

Article

Disciplines

Immunology and Infectious Disease

Abstract

Several heat shock proteins (HSPs) prime immune responses, which are, in part, a result of activation of APCs. APCs respond to these immunogenic HSPs by upregulating costimulatory molecules and secreting cytokines, including IL-1beta. These HSP-mediated responses are central mediators in pathological conditions ranging from cancer, sterile inflammation associated with trauma, and rheumatoid arthritis. We tested in this study the requirement of inflammasomes in the release of IL-1beta by one immunogenic HSP, gp96. Our results show that murine APCs activate NLRP3 inflammasomes in response to gp96 by K(+) efflux. This is shown to initiate inflammatory conditions in vivo in the absence of additional known inflammasome activators or infection. These results document a novel mechanism by which proteins of endogenous origin, the HSPs, can modulate an inflammatory response following their release from aberrant cells.

Keywords

heat shock proteins, immune responses, cytokines

Rights and Permissions

Copyright © 2018 by The American Association of Immunologists, Inc. Publisher's PDF posted as allowed by publisher's Author Choice policy at: http://www.jimmunol.org/info/authorchoice.

DOI of Published Version

10.4049/jimmunol.1800505

Source

J Immunol. 2018 Oct 15;201(8):2209-2214. doi: 10.4049/jimmunol.1800505. Epub 2018 Sep 12. Link to article on publisher's site

Journal/Book/Conference Title

Journal of immunology (Baltimore, Md. : 1950)

Related Resources

Link to Article in PubMed

PubMed ID

30209191

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