UMMS Affiliation

Department of Medicine

Publication Date

2018-9

Document Type

Article

Disciplines

Amino Acids, Peptides, and Proteins | Genetics and Genomics | Immunoprophylaxis and Therapy | Therapeutics

Abstract

DNA vaccines were pioneered by several groups in the early 1990s. This article presents the reflections of one of these groups on their work with retroviral vectors in chickens that contributed to the discovery and early development of DNA vaccines. Although the findings were initially met with skepticism, the work presented here combined with that of others founded a new method of vaccination: the direct inoculation of purified DNA encoding the target antigen.

Keywords

DNA vaccines, antibody, cytotoxic T cells, heterologous prime-boost

Rights and Permissions

Copyright Ellen F. Fynan et al. 2018; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

DOI of Published Version

10.1089/hum.2018.066

Source

Hum Gene Ther. 2018 Sep;29(9):966-970. doi: 10.1089/hum.2018.066. Epub 2018 Aug 21. Link to article on publisher's site

Journal/Book/Conference Title

Human gene therapy

Related Resources

Link to Article in PubMed

PubMed ID

30129778

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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