UMMS Affiliation
Department of Molecular, Cell and Cancer Biology
Publication Date
2018-08-03
Document Type
Editorial
Disciplines
Amino Acids, Peptides, and Proteins | Cell Biology | Cells | Cellular and Molecular Physiology | Enzymes and Coenzymes
Abstract
Critical mediators of apoptotic cell death are caspases, a highly specialized class of Cys-proteases that cleave substrates after Asp residues. Under normal conditions, caspases are cytosolic proteins. After their activation, they cleave a large number of cytosolic proteins and execute apoptosis (Figure 1, left). However, in addition to their well-studied role in apoptosis, caspases also have many non-apoptotic functions [1, 2]. It is not very well understood how cells escape the potential harmful action of caspases when they perform nonapoptotic functions. In our recent work, we now show that epithelial cells may prevent apoptosis by sequestration of caspases at the plasma membrane, specifically the basal side of the plasma membrane, for non-apoptotic functions [3].
Keywords
apoptosis-induced proliferation, undead cells, caspase, Myo1D, plasma membrane
Rights and Permissions
Copyright: Bergmann et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI of Published Version
10.18632/oncotarget.25796
Source
Oncotarget. 2018 Aug 3;9(60):31566-31567. doi: 10.18632/oncotarget.25796. eCollection 2018 Aug 3. Link to article on publisher's site
Journal/Book/Conference Title
Oncotarget
Related Resources
PubMed ID
30167077
Repository Citation
Bergmann, Andreas, "Are membranes non-apoptotic compartments for apoptotic caspases" (2018). Open Access Articles. 3561.
https://escholarship.umassmed.edu/oapubs/3561
Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.
Included in
Amino Acids, Peptides, and Proteins Commons, Cell Biology Commons, Cells Commons, Cellular and Molecular Physiology Commons, Enzymes and Coenzymes Commons