UMMS Affiliation

Department of Medicine

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Document Type



Cardiovascular Diseases | Diagnosis | Hematology | Hemic and Lymphatic Diseases | Neoplasms | Pathological Conditions, Signs and Symptoms | Tissues


Primary cardiac lymphoma (PCL) is a rare disease entity that can present with severe cardiac and cardioembolic symptoms. We present a 79-year-old male with history of polymalgia rheumatica on chronic prednisone who presented with a two-week history of progressively worsening dyspnea, cough, and a 10 pound weight loss. Transthoracic echocardiogram (TTE) and computed tomography (CT) of the chest showed a large mediastinal mass with invasion of the pericardium. A biopsy of an abdominal soft-tissue mass confirmed the diagnosis of PCL. The patient was treated with two cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) which was complicated by progressive heart failure requiring substitution of liposomal doxorubicin. The epidemiology, presentation, diagnosis, and treatment options of PCL are discussed.

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Copyright © 2018 Lauren Mendelson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

DOI of Published Version



Case Rep Hematol. 2018 Jul 25;2018:6192452. doi: 10.1155/2018/6192452. eCollection 2018. Link to article on publisher's site

Journal/Book/Conference Title

Case reports in hematology

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PubMed ID


Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.