Impact of delirium on patients hospitalized for myocardial infarction: A propensity score analysis of the National Inpatient Sample

UMMS Affiliation

Department of Medicine

Publication Date


Document Type



Cardiology | Cardiovascular Diseases | Clinical Epidemiology | Epidemiology | Nervous System Diseases | Pathological Conditions, Signs and Symptoms | Psychiatry and Psychology


BACKGROUND: Delirium is associated with worse outcomes in critically ill patients. In the subset of patients with myocardial infarction (MI), the impact on clinical outcomes of delirium is not as well elucidated.

HYPOTHESIS: Delirium is associated with increased mortality in patients hospitalized for MI.

METHODS: The study used data from the National Inpatient Sample 2012 to 2014, Healthcare Cost and Utilization Project. We included discharges associated with the primary diagnosis of MI using the relevant International Classification of Diseases, Ninth Revision, Clinical Modification codes. The outcome was inpatient mortality between the delirium group and propensity score-matched controls without delirium.

RESULTS: The study included 1 330 020 weighted discharges with MI as the principal diagnosis. Within this cohort, 18 685 discharges (1.4%) had delirium. Delirium was associated with older age, lower rates of percutaneous coronary intervention, and increased comorbid conditions. The delirium group had higher mortality (10.5% vs 2.6%, P < 0.001). Propensity score-matching analysis showed increased mortality in the delirium group (10.5% vs 7.6%, relative risk: 1.39 [95% confidence interval: 1.2-1.6, P < 0.001) using nearest neighbor 1:1 matching.

CONCLUSIONS: In individuals with MI, delirium was associated with increased inpatient mortality.


Clinical Modification Codes, International Classification of Diseases, Ninth Revision, Altered Mental Status, Comorbidities, Delirium, Myocardial Infarction

DOI of Published Version



Clin Cardiol. 2018 Jul;41(7):910-915. doi: 10.1002/clc.22972. Epub 2018 Jul 20. Link to article on publisher's site

Journal/Book/Conference Title

Clinical cardiology

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Link to Article in PubMed

PubMed ID