Department of Microbiology and Physiological Systems
Bacteria | Biochemical Phenomena, Metabolism, and Nutrition | Carbohydrates | Dietetics and Clinical Nutrition | Ecology and Evolutionary Biology | Genetic Phenomena | Genetics and Genomics | Microbiology | Nutrition
Bifidobacterium is a diverse genus of anaerobic, saccharolytic bacteria that colonize many animals, notably humans and other mammals. The presence of these bacteria in the gastrointestinal tract represents a potential coevolution between the gut microbiome and its mammalian host mediated by diet. To study the relationship between bifidobacterial gut symbionts and host nutrition, we analyzed the genome of two bifidobacteria strains isolated from the feces of a common marmoset (Callithrix jacchus), a primate species studied for its ability to subsist on host-indigestible carbohydrates. Whole genome sequencing identified these isolates as unique strains of Bifidobacterium callitrichos. All three strains, including these isolates and the previously described type strain, contain genes that may enable utilization of marmoset dietary substrates. These include genes predicted to contribute to galactose, arabinose, and trehalose metabolic pathways. In addition, significant genomic differences between strains suggest that bifidobacteria possess distinct roles in carbohydrate metabolism within the same host. Thus, bifidobacteria utilize dietary components specific to their host, both humans and non-human primates alike. Comparative genomics suggests conservation of possible coevolutionary relationships within the primate clade.
bifidobacteria, comparative genomics, gut microbiota, commensalism, non-human primate
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Copyright 2018 The Authors. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
DOI of Published Version
Microb Genom. 2018 Jun 15. doi: 10.1099/mgen.0.000183. [Epub ahead of print] Link to article on publisher's site
Albert K, Rani A, Sela DA. (2018). The comparative genomics of Bifidobacterium callitrichos reflects dietary carbohydrate utilization within the common marmoset gut. Open Access Articles. https://doi.org/10.1099/mgen.0.000183. Retrieved from https://escholarship.umassmed.edu/oapubs/3512
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