UMMS Affiliation

Department of Microbiology and Physiological Systems

Publication Date

2018-06-15

Document Type

Article

Disciplines

Bacteria | Biochemical Phenomena, Metabolism, and Nutrition | Carbohydrates | Dietetics and Clinical Nutrition | Ecology and Evolutionary Biology | Genetic Phenomena | Genetics and Genomics | Microbiology | Nutrition

Abstract

Bifidobacterium is a diverse genus of anaerobic, saccharolytic bacteria that colonize many animals, notably humans and other mammals. The presence of these bacteria in the gastrointestinal tract represents a potential coevolution between the gut microbiome and its mammalian host mediated by diet. To study the relationship between bifidobacterial gut symbionts and host nutrition, we analyzed the genome of two bifidobacteria strains isolated from the feces of a common marmoset (Callithrix jacchus), a primate species studied for its ability to subsist on host-indigestible carbohydrates. Whole genome sequencing identified these isolates as unique strains of Bifidobacterium callitrichos. All three strains, including these isolates and the previously described type strain, contain genes that may enable utilization of marmoset dietary substrates. These include genes predicted to contribute to galactose, arabinose, and trehalose metabolic pathways. In addition, significant genomic differences between strains suggest that bifidobacteria possess distinct roles in carbohydrate metabolism within the same host. Thus, bifidobacteria utilize dietary components specific to their host, both humans and non-human primates alike. Comparative genomics suggests conservation of possible coevolutionary relationships within the primate clade.

Keywords

bifidobacteria, comparative genomics, gut microbiota, commensalism, non-human primate

Rights and Permissions

Copyright 2018 The Authors. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

DOI of Published Version

10.1099/mgen.0.000183

Source

Microb Genom. 2018 Jun 15. doi: 10.1099/mgen.0.000183. [Epub ahead of print] Link to article on publisher's site

Journal/Book/Conference Title

Microbial genomics

Related Resources

Link to Article in PubMed

PubMed ID

29906260

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.