Department of Medicine; Meyers Primary Care Institute
Clinical Epidemiology | Hematology | Hemic and Lymphatic Diseases | Immune System Diseases | Immunopathology | Neoplasms | Pathological Conditions, Signs and Symptoms
Inflammation and B-cell hyperactivation have been associated with non-Hodgkin lymphoma development. This prospective analysis aimed to further elucidate pre-diagnosis plasma immune marker profiles associated with non-Hodgkin lymphoma risk. We identified 598 incident lymphoma cases and 601 matched controls in Nurses' Health Study and Health Professionals Follow-up Study participants with archived pre-diagnosis plasma samples and measured 13 immune marker levels with multiplexed immunoassays. Using multivariable logistic regression we calculated odds ratios and 95% confidence intervals per standard deviation unit increase in biomarker concentration for risk of non-Hodgkin lymphoma and major histologic subtype, stratifying additional models by years ( < 5, 5 to < 10, > /=10) after blood draw. Soluble interleukin-2 receptor-alpha, CXC chemokine ligand 13, soluble CD30, and soluble tumor necrosis factor receptor-2 were individually positively associated, and B-cell activating factor of the tumor necrosis factor family inversely associated, with all non-Hodgkin lymphoma and one or more subtypes. The biomarker combinations associated independently with lymphoma varied somewhat by subtype and years after blood draw. Of note, the unexpected inverse association between B-cell activating factor and chronic lymphocytic leukemia/small lymphocytic lymphoma risk (odds ratio: 95% confidence interval: 0.51, 0.43-0.62) persisted more than 10 years after blood draw (odds ratio: 0.70; 95% confidence interval: 0.52-0.93). In conclusion, immune activation precedes non-Hodgkin lymphoma diagnosis by several years. Decreased B-cell activating factor levels may denote nascent chronic lymphocytic leukemia many years pre-diagnosis.
Aggressive Non-Hodgkin's Lymphoma, Chronic Lymphocytic Leukemia, Clinical and Molecular Epidemiology, Indolent Non-Hodgkin's Lymphoma, UMCCTS funding
Rights and Permissions
Copyright © 2018, Ferrata Storti Foundation. Authors' accepted manuscript posted as allowed by the publisher's author rights policy at http://www.haematologica.org/information-for-authors.
DOI of Published Version
Haematologica. 2018 Jun 21. pii: haematol.2017.183236. doi: 10.3324/haematol.2017.183236. [Epub ahead of print] Link to article on publisher's site
Epstein, Mara M.; Rosner, Bernard; Breen, Elizabeth C.; Batista, Julie L.; Giovannucci, Edward L.; Magpantay, Larry; Aster, Jon C.; Rodig, Scott J.; Bertrand, Kimberly A.; Laden, Francine; Martinez-Maza, Otoniel; and Birmann, Brenda M., "Pre-diagnosis plasma immune markers and risk of non-Hodgkin lymphoma in two prospective cohort studies" (2018). Open Access Articles. 3503.
Clinical Epidemiology Commons, Hematology Commons, Hemic and Lymphatic Diseases Commons, Immune System Diseases Commons, Immunopathology Commons, Neoplasms Commons, Pathological Conditions, Signs and Symptoms Commons