Department of Radiation Oncology; Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine; Department of Orthopedics and Physical Rehabilitation; Department of Surgery
Clinical Epidemiology | Epidemiology | Medicine and Health | Neoplasms | Oncology
Background: Little is understood regarding the inter-relation between economic, marital, and racial/ethnic differences in presentation and survival of surgically resected lung cancer patients. Our investigation will assess these differences in addition to known therapeutic, patient, and histopathologic factors.
Methods: A retrospective review of the Surveillance Epidemiology and End Reporting database was conducted through the years 2007-2012. The population was split into nine different ethnic groups. Population differences were assessed via chi-square testing. Multivariable analysis (MVA) were used to detect overall survival (OS) differences in the total surgical population (TS, N = 35,689) in an ear (T1-T2 < 4 cm N0) surgical population [early-stage resectable (ESR), N = 17,931]. Lung cancer-specific survival (LCSS) was assessed in the ESR.
Results: In the TS population, as compared to Whites, Blacks, and Hispanics presented with younger age, more adenocarcinomas, lower rates of marriage, lower rates of insurance, less stage I tumors, and had less nodes examined, but their type of surgical procedures and OS/LCSS were the same. MVA demonstrated that lower OS and LCSS were associated with males, single/divorced/widowed partnership, lower income (TS only), and Medicaid insurance. MVA also found that Blacks and Hispanics had a similar OS/LCSS to Whites and that all ethnic groups were associated with a similar or better outcomes. The 90-day mortality and positive nodes were correlated with not having insurance and not being married, but they were not associated with ethnicity.
Conclusion: In TS and ESR groups, OS was not different in the two largest ethnic groups (Black and Hispanic) as compared to Whites, but was related to single/widowed/divorced status, Medicaid insurance, and income (TS group only). Nodal positivity was associated with patients who did not have a married partner or insurance suggesting that these factors may impact disease biology. Economic and psychosocial variables may play a role in survival of ear lung cancer in addition to standard histopathologic and treatment variables.
Lung cancer, marital status, racial differences, socioeconomic status, surgical resection
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Copyright © 2018 Varlotto, McKie, Voland, Flickinger, DeCamp, Maddox, Rava, Fitzgerald, Walsh, Oliveira, Rassaei, Baima and Uy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
DOI of Published Version
Front Oncol. 2018 May 14;8:146. doi: 10.3389/fonc.2018.00146. eCollection 2018. Link to article on publisher's site
Frontiers in oncology
Varlotto, John M.; McKie, Kerrie; Voland, Rickie P.; Flickinger, John C.; DeCamp, Malcolm M.; Maddox, Debra; Rava, Paul; Fitzgerald, Thomas J.; Walsh, William; Oliveira, Paulo; Rassaei, Negar; Baima, Jennifer; and Uy, Karl, "The Role of Race and Economic Characteristics in the Presentation and Survival of Patients With Surgically Resected Non-Small Cell Lung Cancer" (2018). Open Access Articles. 3481.
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