IL-15 supports the generation of protective lung-resident memory CD4 T cells
Department of Pathology
Immunology of Infectious Disease | Immunopathology | Pathological Conditions, Signs and Symptoms | Respiratory Tract Diseases | Virus Diseases
Tissue-resident memory T cells (TRM) provide optimal defense at the sites of infection, but signals regulating their development are unclear, especially for CD4 T cells. Here we identify two distinct pathways that lead to the generation of CD4 TRM in the lungs following influenza infection. The TRM are transcriptionally distinct from conventional memory CD4 T cells and share a gene signature with CD8 TRM. The CD4 TRM are superior cytokine producers compared with conventional memory cells, can protect otherwise naive mice against a lethal influenza challenge, and display functional specialization by inducing enhanced inflammatory responses from dendritic cells compared with conventional memory cells. Finally, we demonstrate than an interleukin (IL)-2-dependent and a novel IL-2-independent but IL-15-dependent pathway support the generation of cohorts of lung TRM.
DOI of Published Version
Mucosal Immunol. 2018 May;11(3):668-680. doi: 10.1038/mi.2017.101. Epub 2017 Nov 29. Link to article on publisher's site
Strutt TM, Dhume K, Finn CM, Hwang JH, Castonguay C, Swain SL, McKinstry KK. (2018). IL-15 supports the generation of protective lung-resident memory CD4 T cells. Open Access Publications by UMass Chan Authors. https://doi.org/10.1038/mi.2017.101. Retrieved from https://escholarship.umassmed.edu/oapubs/3468