IL-15 supports the generation of protective lung-resident memory CD4 T cells
Authors
Strutt, T. M.Dhume, K.
Finn, C. M.
Hwang, J. H.
Castonguay, Catherine
Swain, Susan L.
McKinstry, K. K.
UMass Chan Affiliations
Department of PathologyDocument Type
Journal ArticlePublication Date
2018-05-01Keywords
Immunology of Infectious DiseaseImmunopathology
Pathological Conditions, Signs and Symptoms
Respiratory Tract Diseases
Virus Diseases
Metadata
Show full item recordAbstract
Tissue-resident memory T cells (TRM) provide optimal defense at the sites of infection, but signals regulating their development are unclear, especially for CD4 T cells. Here we identify two distinct pathways that lead to the generation of CD4 TRM in the lungs following influenza infection. The TRM are transcriptionally distinct from conventional memory CD4 T cells and share a gene signature with CD8 TRM. The CD4 TRM are superior cytokine producers compared with conventional memory cells, can protect otherwise naive mice against a lethal influenza challenge, and display functional specialization by inducing enhanced inflammatory responses from dendritic cells compared with conventional memory cells. Finally, we demonstrate than an interleukin (IL)-2-dependent and a novel IL-2-independent but IL-15-dependent pathway support the generation of cohorts of lung TRM.Source
Mucosal Immunol. 2018 May;11(3):668-680. doi: 10.1038/mi.2017.101. Epub 2017 Nov 29. Link to article on publisher's site
DOI
10.1038/mi.2017.101Permanent Link to this Item
http://hdl.handle.net/20.500.14038/40666PubMed ID
29186108Related Resources
ae974a485f413a2113503eed53cd6c53
10.1038/mi.2017.101