Department of Biochemistry and Molecular Pharmacology; Thompson Lab
Amino Acids, Peptides, and Proteins | Biochemistry | Chemical and Pharmacologic Phenomena | Chemicals and Drugs | Medicinal-Pharmaceutical Chemistry
Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been made available to academia. However, probe-associated data and control compounds, such as inactive structurally related molecules and their associated data, are generally not accessible. The lack of data and guidance makes it difficult for researchers to decide which chemical tools to choose. Several pharmaceutical companies (AbbVie, Bayer, Boehringer Ingelheim, Janssen, MSD, Pfizer, and Takeda) have therefore entered into a pre-competitive collaboration to make available a large number of innovative high-quality probes, including all probe-associated data, control compounds and recommendations on use (https://openscienceprobes.sgc-frankfurt.de/). Here we describe the chemical tools and target-related knowledge that have been made available, and encourage others to join the project.
Chemical probes, Open Science, Target validation, biochemistry, chemical biology
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Copyright 2018 Muller et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
DOI of Published Version
Elife. 2018 Apr 20;7. pii: 34311. doi: 10.7554/eLife.34311. Link to article on publisher's site
Muller, Susanne; Thompson, Paul R.; and Mueller-Fahrnow, Anke, "Donated chemical probes for open science" (2018). Open Access Articles. 3442.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.