UMMS Affiliation

Department of Medicine, Division of Infectious Diseases And Immunology; Department of Medicine, Division of Community Internal Medicine

Publication Date


Document Type



Cardiovascular Diseases | Infectious Disease | Virus Diseases | Viruses


Splenic infarction is a rare complication of infectious mononucleosis. We describe 3 cases of splenic infarction attributed to infectious mononucleosis that we encountered within a 2-month period. We underscore the awareness of this potential complication of infectious mononucleosis and discuss the differential diagnosis of splenic infarction, including infectious etiologies. While symptomatic management is usually sufficient for infectious mononucleosis-associated splenic infarction, close monitoring for other complications, including splenic rupture, is mandated.


Epstein-Barr virus, infectious mononucleosis, splenic infarction

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© The Author(s) 2018. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (, which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact

DOI of Published Version



Open Forum Infect Dis. 2018 Feb 17;5(3):ofy041. doi: 10.1093/ofid/ofy041. eCollection 2018 Mar. Link to article on publisher's site

Journal/Book/Conference Title

Open forum infectious diseases

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Link to Article in PubMed

PubMed ID


Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.