UMMS Affiliation
Department of Neurology
Publication Date
2018-02-21
Document Type
Article
Disciplines
Biology | Computational Biology | Computational Neuroscience | Computer Sciences
Abstract
The ability to define the unique features of an input stimulus needed to control switch-like behavior in biological systems is an important problem in computational biology and medicine. We show in this study how highly complex and intractable optimization problems can be simplified by restricting the search to the signal's extrema as key feature points, and evolving the extrema features towards optimal solutions that closely match solutions derived from gradient-based methods. Our results suggest a model-independent approach for solving a class of optimization problems related to controlling switch-like state transitions.
Keywords
Computational models, Computational neuroscience, Dynamical systems
Rights and Permissions
Copyright © The Author(s) 2018. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
DOI of Published Version
10.1038/s41598-018-21761-8
Source
Sci Rep. 2018 Feb 21;8(1):3403. doi: 10.1038/s41598-018-21761-8. Link to article on publisher's site
Journal/Book/Conference Title
Scientific reports
Related Resources
PubMed ID
29467377
Repository Citation
Chang, Joshua TsuKang and Paydarfar, David, "Evolution of extrema features reveals optimal stimuli for biological state transitions" (2018). Open Access Articles. 3392.
https://escholarship.umassmed.edu/oapubs/3392
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Included in
Biology Commons, Computational Biology Commons, Computational Neuroscience Commons, Computer Sciences Commons