Department of Medicine, Division of Pulmonary, Allergy And Critical Care Medicine
Bacterial Infections and Mycoses | Epidemiology | Immunology and Infectious Disease | Infectious Disease | Pulmonology | Respiratory System | Respiratory Tract Diseases
A past history of pulmonary tuberculosis (TB) is a risk factor for long-term respiratory impairment. Post-TB lung dysfunction often goes unrecognised, despite its relatively high prevalence and its association with reduced quality of life. Importantly, specific host and pathogen factors causing lung impairment remain unclear. Host immune responses probably play a dominant role in lung damage, as excessive inflammation and elevated expression of lung matrix-degrading proteases are common during TB. Variability in host genes that modulate these immune responses may determine the severity of lung impairment, but this hypothesis remains largely untested. In this review, we provide an overview of the epidemiological literature on post-TB lung impairment and link it to data on the pathogenesis of lung injury from the perspective of dysregulated immune responses and immunogenetics.
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Copyright © ERS 2018. ERR articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
DOI of Published Version
Eur Respir Rev. 2018 Feb 28;27(147). pii: 170077. doi: 10.1183/16000617.0077-2017. Print 2018 Mar 31. Link to article on publisher's site
European respiratory review : an official journal of the European Respiratory Society
Ravimohan S, Kornfeld H, Weissman D, Bisson GP. (2018). Tuberculosis and lung damage: from epidemiology to pathophysiology. Open Access Articles. https://doi.org/10.1183/16000617.0077-2017. Retrieved from https://escholarship.umassmed.edu/oapubs/3388
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
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