UMMS Affiliation

Department of Microbiology and Physiological Systems

Publication Date

2018-01-28

Document Type

Article

Disciplines

Ecology and Evolutionary Biology | Immunology and Infectious Disease | Pathogenic Microbiology | Population Biology | Virology | Virus Diseases | Viruses

Abstract

Human cytomegalovirus (HCMV) is a member of the beta -herpesvirus subfamily within Herpesviridae that is nearly ubiquitous in human populations, and infection generally results only in mild symptoms. However, symptoms can be severe in immunonaive individuals, and transplacental congenital infection of HCMV can result in serious neurological sequelae. Recent work has revealed much about the demographic and selective forces shaping the evolution of congenitally transmitted HCMV both on the level of hosts and within host compartments, providing insight into the dynamics of congenital infection, reinfection, and evolution of HCMV with important implications for the development of effective treatments and vaccines.

Keywords

human cytomegalovirus, population genetics, viral evolution

Rights and Permissions

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

DOI of Published Version

10.3390/pathogens7010016

Source

Pathogens. 2018 Jan 28;7(1). pii: E16. doi: 10.3390/pathogens7010016. Link to article on publisher's site

Journal/Book/Conference Title

Pathogens (Basel, Switzerland)

Related Resources

Link to Article in PubMed

PubMed ID

29382090

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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