UMMS Affiliation

Department of Microbiology and Physiological Systems

Publication Date


Document Type



Ecology and Evolutionary Biology | Immunology and Infectious Disease | Pathogenic Microbiology | Population Biology | Virology | Virus Diseases | Viruses


Human cytomegalovirus (HCMV) is a member of the beta -herpesvirus subfamily within Herpesviridae that is nearly ubiquitous in human populations, and infection generally results only in mild symptoms. However, symptoms can be severe in immunonaive individuals, and transplacental congenital infection of HCMV can result in serious neurological sequelae. Recent work has revealed much about the demographic and selective forces shaping the evolution of congenitally transmitted HCMV both on the level of hosts and within host compartments, providing insight into the dynamics of congenital infection, reinfection, and evolution of HCMV with important implications for the development of effective treatments and vaccines.


human cytomegalovirus, population genetics, viral evolution

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© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (

DOI of Published Version



Pathogens. 2018 Jan 28;7(1). pii: E16. doi: 10.3390/pathogens7010016. Link to article on publisher's site

Journal/Book/Conference Title

Pathogens (Basel, Switzerland)

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PubMed ID


Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.