Department of Microbiology and Physiological Systems
Ecology and Evolutionary Biology | Immunology and Infectious Disease | Pathogenic Microbiology | Population Biology | Virology | Virus Diseases | Viruses
Human cytomegalovirus (HCMV) is a member of the beta -herpesvirus subfamily within Herpesviridae that is nearly ubiquitous in human populations, and infection generally results only in mild symptoms. However, symptoms can be severe in immunonaive individuals, and transplacental congenital infection of HCMV can result in serious neurological sequelae. Recent work has revealed much about the demographic and selective forces shaping the evolution of congenitally transmitted HCMV both on the level of hosts and within host compartments, providing insight into the dynamics of congenital infection, reinfection, and evolution of HCMV with important implications for the development of effective treatments and vaccines.
human cytomegalovirus, population genetics, viral evolution
Rights and Permissions
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
DOI of Published Version
Pathogens. 2018 Jan 28;7(1). pii: E16. doi: 10.3390/pathogens7010016. Link to article on publisher's site
Pathogens (Basel, Switzerland)
Sackman AM, Pfeifer SP, Kowalik TF, Jensen JD. (2018). On the Demographic and Selective Forces Shaping Patterns of Human Cytomegalovirus Variation within Hosts. Open Access Articles. https://doi.org/10.3390/pathogens7010016. Retrieved from https://escholarship.umassmed.edu/oapubs/3361
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.