UMMS Affiliation

Department of Pediatrics, Division of Hematology Oncology

Publication Date

2017-12-07

Document Type

Letter to the Editor

Disciplines

Hematology | Hemic and Lymphatic Diseases

Abstract

Cyclic neutropenia is a rare hematologic disease that is characterized by regular oscillations in blood neutrophil counts from normal levels (absolute neutrophil count [ANC], >1.5×109 per liter) to severe neutropenia (ANC, <0.2×109 per liter), usually with a cycle length of about 21 days.When patients with this disorder have neutropenia, they often have fever and mouth ulcers and are at risk for severe infections. Cyclic neutropenia is usually an autosomal dominant disorder caused by mutations in the gene encoding neutrophil elastase (ELANE).

Keywords

Cyclic Neutropenia

Rights and Permissions

Copyright © 2017 Massachusetts Medical Society. Publisher PDF posted after 6 months as allowed by the publisher's author rights policy at http://www.nejm.org/author-center/permissions.

DOI of Published Version

10.1056/NEJMc1709258

Source

N Engl J Med. 2017 Dec 7;377(23):2290-2292. doi: 10.1056/NEJMc1709258. Link to article on publisher's site

Journal/Book/Conference Title

The New England journal of medicine

Related Resources

Link to Article in PubMed

PubMed ID

29211670

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