UMMS Affiliation

Department of Pediatrics, Division of Hematology Oncology

Publication Date


Document Type

Letter to the Editor


Hematology | Hemic and Lymphatic Diseases


Cyclic neutropenia is a rare hematologic disease that is characterized by regular oscillations in blood neutrophil counts from normal levels (absolute neutrophil count [ANC], >1.5×109 per liter) to severe neutropenia (ANC, <0.2×109 per liter), usually with a cycle length of about 21 days.When patients with this disorder have neutropenia, they often have fever and mouth ulcers and are at risk for severe infections. Cyclic neutropenia is usually an autosomal dominant disorder caused by mutations in the gene encoding neutrophil elastase (ELANE).


Cyclic Neutropenia

Rights and Permissions

Copyright © 2017 Massachusetts Medical Society. Publisher PDF posted after 6 months as allowed by the publisher's author rights policy at

DOI of Published Version



N Engl J Med. 2017 Dec 7;377(23):2290-2292. doi: 10.1056/NEJMc1709258. Link to article on publisher's site

Journal/Book/Conference Title

The New England journal of medicine

Related Resources

Link to Article in PubMed

PubMed ID




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