Department of Pediatrics, Division of Hematology Oncology
Letter to the Editor
Hematology | Hemic and Lymphatic Diseases
Cyclic neutropenia is a rare hematologic disease that is characterized by regular oscillations in blood neutrophil counts from normal levels (absolute neutrophil count [ANC], >1.5×109 per liter) to severe neutropenia (ANC, <0.2×109 per liter), usually with a cycle length of about 21 days.When patients with this disorder have neutropenia, they often have fever and mouth ulcers and are at risk for severe infections. Cyclic neutropenia is usually an autosomal dominant disorder caused by mutations in the gene encoding neutrophil elastase (ELANE).
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Copyright © 2017 Massachusetts Medical Society. Publisher PDF posted after 6 months as allowed by the publisher's author rights policy at http://www.nejm.org/author-center/permissions.
DOI of Published Version
N Engl J Med. 2017 Dec 7;377(23):2290-2292. doi: 10.1056/NEJMc1709258. Link to article on publisher's site
The New England journal of medicine
Dale, David C.; Bolyard, AudreyAnna; Marrero, Tracy; Makaryan, Vahagn; Bonilla, MaryAnn; Link, Daniel C.; Newburger, Peter E.; Shimamura, Akiko; Boxer, Laurence A.; and Spiekerman, Charles, "Long-Term Effects of G-CSF Therapy in Cyclic Neutropenia" (2017). Open Access Articles. 3344.