UMMS Affiliation

Department of Surgery; Department of Medicine, Division of Gastroenterology; School of Medicine; Senior Scholars Program

Publication Date

2017-12-01

Document Type

Article

Disciplines

Digestive System Diseases | Gastroenterology | Neoplasms | Surgery | Surgical Procedures, Operative

Abstract

Background: Neuroendocine tumors (NETs) or carcinoids arise at many different sites of the gastrointestinal tract. The small intestine is the most common site for NETs. Diagnosing small bowel carcinoids remains challenging given their non-specific presentations and the overall low incidence of small bowel tumors. Video capsule endoscopy (VCE) has significanly improved our ability to detect small bowel malignancies. We explore the value of VCE in the initial workup and management of a series of small bowel carcinoid patients.

Methods: We retrospectively analyzed adult patients undergoing surgical management for small bowel lesions from July 2005 to September 2015 at a tertiary care center. Patient characteristics, presenting symptomatology, diagnostic workup and surgical management were analyzed among patients with histologically confirmed small bowel carcinoid tumors.

Results: Our study identified 16 patients treated surgically for small bowel carcinoids. The majority of patients (87.5%) presented with either occult gastrointestinal bleeding or anemia. Most patients (87.5%) were initially evaluated with various endoscopic and imaging modalities before all ultimately undergoing surgery. Seventy-five percent of patients had a VCE, with 83.3% (10/12) having positive findings that correlated with intraoperative findings compared to 62.5% (5/8) with computed tomography scan, 21.4% (3/14) with colonoscopy, 44% (4/9) with deep enteroscopy, and 0% (0/9) with esophagogastroduodenoscopy (EGD).

Conclusions: In the absence of any contraindications, VCE is an effective endoscopic modality in the diagnostic workup of small bowel NETs. Furthermore, positive VCE findings appear to highly correlate with surgical findings, thus suggesting a valuable role for VCE in the initial surgical assessment of patients with small bowel NETs.

Keywords

Carcinoid, Neuroendocrine tumors, Small bowel, Surgical resection, Video capsule endoscopy

Rights and Permissions

Copyright 2017, Noujaim et al. This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI of Published Version

10.14740/gr937w

Source

Gastroenterology Res. 2017 Dec;10(6):347-351. doi: 10.14740/gr937w. Epub 2018 Jan 3. Link to article on publisher's site

Journal/Book/Conference Title

Gastroenterology research

Comments

Michael Noujaim participated in this study as a medical student as part of the Senior Scholars Program at the University of Massachusetts Medical School.

Related Resources

Link to Article in PubMed

PubMed ID

29317942

Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

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