UMMS Affiliation

Department of Medicine, Division of Endocrinology and Metabolism; Department of Pathology; Department of Medicine, Division of Hematology and Oncology

Publication Date

2017-12-25

Document Type

Article

Disciplines

Endocrine System Diseases | Endocrinology, Diabetes, and Metabolism | Hemic and Lymphatic Diseases | Neoplasms | Otorhinolaryngologic Diseases | Pathology

Abstract

Background: While 2% of all extranodal Non-Hodgkin Lymphomas present in the thyroid, there exists insufficient data to describe the incidence of mantle cell lymphoma in the thyroid. A case series of 1400 patients revealed that < 1% of thyroid lymphomas may be MCL; hence better understanding of the disease course is essential.

Patient Findings: A 65-year-old female was referred for a multinodular goiter. Multiple fine needle aspirations from the dominant right nodule were consistent with Hashimoto's thyroiditis and flow cytometry was negative. Due to progressing dysphagia, she underwent total thyroidectomy.

Summary: Pathology revealed MCL with mantle zone growth pattern in the right thyroid. Flow cytometry showed monoclonal B cells comprising 9% of total cells. The Ki-67 index was 10%. She was diagnosed as having stage IIE MCL and offered conservative management by medical oncology, given that she had no B symptoms.

Conclusion: Though chemotherapy is the treatment of choice in MCL, a subset of patients with low-grade disease may be observed. As in our patient, mantle zone growth pattern and a Ki-67 index < 10% suggest a favorable prognosis. A diagnosis of primary MCL in the thyroid remains rare and staging modalities as well as treatment options continue to evolve.

Keywords

mantle cell lymphoma, thyroid

Rights and Permissions

Copyright © 2017 Uzma Mohammad Siddiqui et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

DOI of Published Version

10.1155/2017/6749801

Source

Case Rep Pathol. 2017;2017:6749801. doi: 10.1155/2017/6749801. Epub 2017 Dec 25. Link to article on publisher's site

Journal/Book/Conference Title

Case reports in pathology

Related Resources

Link to Article in PubMed

PubMed ID

29435379

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.