UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Publication Date

9-1-2017

Document Type

Article

Disciplines

Molecular and Cellular Neuroscience | Nervous System Diseases

Abstract

Microglia are brain-resident myeloid cells that mediate key functions to support the CNS. Microglia express a wide range of receptors that act as molecular sensors, which recognize exogenous or endogenous CNS insults and initiate an immune response. In addition to their classical immune cell function, microglia act as guardians of the brain by promoting phagocytic clearance and providing trophic support to ensure tissue repair and maintain cerebral homeostasis. Conditions associated with loss of homeostasis or tissue changes induce several dynamic microglial processes, including changes of cellular morphology, surface phenotype, secretory mediators, and proliferative responses (referred to as an "activated state"). Activated microglia represent a common pathological feature of several neurodegenerative diseases, including Alzheimer's disease (AD). Cumulative evidence suggests that microglial inflammatory activity in AD is increased while microglial-mediated clearance mechanisms are compromised. Microglia are perpetually engaged in a mutual interaction with the surrounding environment in CNS; thus, diverse microglial reactions at different disease stages may open new avenues for therapeutic intervention and modification of inflammatory activities. In this Review, the role of microglia in the pathogenesis of AD and the modulation of microglia activity as a therapeutic modality will be discussed.

Keywords

microglia, Alzheimer's disease, glia, neurodegeneration

Rights and Permissions

Copyright © 2017, American Society for Clinical Investigation. Publisher PDF posted as allowed by the publisher's terms of use at https://www.jci.org/kiosks/terms.

DOI of Published Version

10.1172/JCI90606

Source

J Clin Invest. 2017 Sep 1;127(9):3240-3249. doi: 10.1172/JCI90606. Epub 2017 Sep 1. Link to article on publisher's site

Journal/Book/Conference Title

The Journal of clinical investigation

Related Resources

Link to Article in PubMed

PubMed ID

28862638

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