UMMS Affiliation

Department of Molecular, Cell and Cancer Biology

Publication Date


Document Type



Cellular and Molecular Physiology


Robust mitochondrial respiration provides energy to support physical performance and physiological well-being, whereas mitochondrial malfunction is associated with various pathologies and reduced longevity. In the current study, we tested whether myricetin, a natural flavonol with diverse biological activities, may impact mitochondrial function and longevity. The mice were orally administered myricetin (50 mg/kg/day) for 3 weeks. Myricetin significantly potentiated aerobic capacity in mice, as evidenced by their increased running time and distance. The elevated mitochondrial function was associated with induction of genes for oxidative phosphorylation and mitochondrial biogenesis in metabolically active tissues. Importantly, myricetin treatment led to decreased PGC-1alpha acetylation through SIRT1 activation. Furthermore, myricetin significantly improved the healthspan and lifespan of wild-type, but not Sir-2.1-deficient, C. elegans. These results demonstrate that myricetin enhances mitochondrial activity, possibly by activating PGC-1alpha and SIRT1, to improve physical endurance, strongly suggesting myricetin as a mitochondria-activating agent.


Ageing, Energy metabolism

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DOI of Published Version



Sci Rep. 2017 Jul 24;7(1):6237. doi: 10.1038/s41598-017-05303-2. Link to article on publisher's site

Journal/Book/Conference Title

Scientific reports


Full author list omitted for brevity. For the full list of authors, see article.

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PubMed ID


Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.