UMMS Affiliation
Department of Medicine, Division of Preventive and Behavioral Medicine
Publication Date
2017-06-05
Document Type
Article
Disciplines
Immunity | Immunoprophylaxis and Therapy | Virology | Virus Diseases | Viruses
Abstract
Previous studies have shown that DNA prime, Ad5 boost vaccines protect against neutralization-sensitive but not neutralization-resistant virus variants within the SIVsmE660 swarm. Here we show that Ad prime, Env protein boost vaccines protect against neutralization-resistant SIVsmE660 variants. We perform two studies in rhesus monkeys with Ad35/Ad26 vectors expressing SIVmac239 Gag/Pol/Env with or without an AS01B-adjuvanted SIVmac32H gp140 protein boost. In a repetitive, low-dose challenge study, we observe robust protection against acquisition of infection by both Ad Alone and Ad/Env vaccines. In a single, high-dose challenge study, only the Ad/Env vaccine affords significant protection against acquisition of infection. Analysis of transmitted/founder (T/F) viruses from this study demonstrates that the Ad/Env vaccine blocks both neutralization-sensitive and neutralization-resistant SIVsmE660 variants in rhesus monkeys with restrictive TRIM5alpha alleles. These data demonstrate that the adjuvanted Env protein boost is critical for protecting against high-dose SIVsmE660 challenge and for blocking neutralization-resistant viruses within the SIVsmE660 swarm.
Keywords
Adaptive immunity, HIV infections, Vaccines
Rights and Permissions
Copyright © 2017, The Author(s)
DOI of Published Version
10.1038/ncomms15740
Source
Nat Commun. 2017 Jun 5;8:15740. doi: 10.1038/ncomms15740. Link to article on publisher's site
Journal/Book/Conference Title
Nature communications
Related Resources
PubMed ID
28580942
Repository Citation
Keele BF, Li W, Borducchi EN, Nkolola JP, Abbink P, Chen B, Seaman MS, Barouch DH. (2017). Adenovirus prime, Env protein boost vaccine protects against neutralization-resistant SIVsmE660 variants in rhesus monkeys. Open Access Articles. https://doi.org/10.1038/ncomms15740. Retrieved from https://escholarship.umassmed.edu/oapubs/3188
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
Included in
Immunity Commons, Immunoprophylaxis and Therapy Commons, Virology Commons, Virus Diseases Commons, Viruses Commons