Department of Ophthalmology
Eye Diseases | Ophthalmology
PURPOSE: The aim was to report the aqueous humor moxifloxacin concentration and proteome profile of an individual with bilateral uveitis-like syndrome with pigment dispersion.
METHODS: Multiple reactions monitoring mass spectrometry quantified the aqueous concentration of moxifloxacin in the affected individual. Shotgun proteomic analysis performed via liquid chromatography tandem mass spectrometry (LC-MS/MS) defined the protein profile in the affected individual and unaffected control samples.
RESULTS: Moxifloxacin was present at higher than expected levels in aqueous humor 18 days following oral administration. One-third of the proteins were identified by significantly lower spectral counts in the aqueous of the individual with moxifloxacin associated uveitis compared to the unaffected control.
CONCLUSION: Moxifloxacin was detected in aqueous humor 18 days following the completion of oral administration. These results suggest that moxifloxacin toxicity may be responsible for the uveitis-like syndrome with pigment dispersion syndrome induced by moxifloxacin therapy.
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Copyright © 2017 Hinkle et al.
DOI of Published Version
Open Ophthalmol J. 2017 Jun 12;11:107-116. doi: 10.2174/1874364101711010107. eCollection 2017. Link to article on publisher's site
The open ophthalmology journal
Hinkle, David M.; Kruh-Garcia, Nicole A.; Kruh, Jonathan N.; Broccardo, Carolyn; Doctor, Priyanka; and Foster, C. Stephen, "Moxifloxacin Concentration and Proteomic Analysis of Aqueous Humor in Human Uveitis Associated with Oral Moxifloxacin Therapy" (2017). Open Access Articles. 3182.
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