Title
Alberta Stroke Program Early CT Score Infarct Location Predicts Outcome Following M2 Occlusion
UMMS Affiliation
Department of Neurology; Millennium PhD Program, Graduate School of Biomedical Sciences
Publication Date
2017-03-14
Document Type
Article
Disciplines
Nervous System Diseases | Neurology
Abstract
BACKGROUND: Although it is generally thought that patients with distal middle cerebral artery (M2) occlusion have a favorable outcome, it has previously been demonstrated that a substantial minority will have a poor outcome by 90 days. We sought to determine whether assessing the Alberta Stroke Program Early CT Score (ASPECTS) infarct location allows for identifying patients at risk for a poor 90-day outcome.
METHODS: We retrospectively analyzed patients with isolated acute M2 occlusion admitted to a single academic center between January 2010 and August 2012. Infarct regions were defined according to ASPECTS system on the initial head computed tomography. Discriminant function analysis was used to define specific ASPECTS regions that are predictive of the 90-day functional outcome as defined as a modified Rankin Scale score of 3-6. In addition, logistic regression was used to model the relationship between each individual ASPECT region with poor outcome; for evaluation and comparison, odds ratios, c-statistics, and Akaike information criterion values were estimated for each region.
RESULTS: Ninety patients with isolated M2 were included in the final analysis. ASPECTS score
CONCLUSION: Infarction in ASPECTS regions M3 and M6 are key predictors of functional outcome following isolated distal M2 occlusion. These findings will be helpful in stratifying outcomes if validated in future studies.
Keywords
Alberta Stroke Program Early CT Score, M2 occlusions, outcome, stroke, thrombolysis
Rights and Permissions
Copyright: © 2017 Khan, Baird, Goddeau, Silver and Henninger.
DOI of Published Version
10.3389/fneur.2017.00098
Source
Front Neurol. 2017 Mar 14;8:98. doi: 10.3389/fneur.2017.00098. eCollection 2017. Link to article on publisher's site
Journal/Book/Conference Title
Frontiers in neurology
Related Resources
PubMed ID
28352248
Repository Citation
Khan, Muhib; Baird, Grayson L.; Goddeau, Richard P.; Silver, Brian; and Henninger, Nils, "Alberta Stroke Program Early CT Score Infarct Location Predicts Outcome Following M2 Occlusion" (2017). Open Access Articles. 3049.
https://escholarship.umassmed.edu/oapubs/3049
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
Co-author Nils Henninger is a doctoral student in the Millennium PhD Program (MPP) in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.