UMMS Affiliation
Department of Neurology; Department of Quantitative Health Sciences; Department of Pediatrics
Publication Date
2017-04-20
Document Type
Article
Disciplines
Congenital, Hereditary, and Neonatal Diseases and Abnormalities | Maternal and Child Health | Neurology | Pediatrics | Substance Abuse and Addiction
Abstract
OBJECTIVE: To examine the therapeutic potential of stochastic vibrotactile stimulation (SVS) as a complementary non-pharmacological intervention for withdrawal in opioid-exposed newborns. STUDY DESIGN: A prospective, within-subjects single-center study was conducted in 26 opioid-exposed newborns ( > 37 weeks; 16 male) hospitalized since birth and treated pharmacologically for Neonatal Abstinence Syndrome. A specially-constructed mattress delivered low-level SVS (30-60Hz, 10-12mum RMS), alternated in 30-min intervals between continuous vibration (ON) and no vibration (OFF) over a 6-8 hr session. Movement activity, heart rate, respiratory rate, axillary temperature and blood-oxygen saturation were calculated separately for ON and OFF. RESULTS: There was a 35% reduction in movement activity with SVS (p<0.001), with significantly fewer movement periods > 30 sec duration for ON than OFF (p = 0.003). Incidents of tachypneic breaths and tachycardic heart beats were each significantly reduced with SVS, whereas incidents of eupneic breaths and eucardic heart beats each significantly increased with SVS (p<0.03). Infants maintained body temperature and arterial-blood oxygen level independent of stimulation condition. CONCLUSIONS: SVS reduced hyperirritability and pathophysiological instabilities commonly observed in pharmacologically-managed opioid-exposed newborns. SVS may provide an effective complementary therapeutic intervention for improving autonomic function in newborns with Neonatal Abstinence Syndrome.
Keywords
stochastic vibrotactile stimulation, opioid-exposed newborns, neonatal drug withdrawal
Rights and Permissions
Copyright © 2017 Zuzarte et al.
DOI of Published Version
10.1371/journal.pone.0175981
Source
PLoS One. 2017 Apr 20;12(4):e0175981. eCollection 2017. Link to article on publisher's site
Journal/Book/Conference Title
PloS one
Related Resources
PubMed ID
28426726
Repository Citation
Zuzarte I, Indic P, Barton BA, Paydarfar D, Bednarek F, Salisbury EB. (2017). Vibrotactile stimulation: A non-pharmacological intervention for opioid-exposed newborns. Open Access Articles. https://doi.org/10.1371/journal.pone.0175981. Retrieved from https://escholarship.umassmed.edu/oapubs/3045
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Included in
Congenital, Hereditary, and Neonatal Diseases and Abnormalities Commons, Maternal and Child Health Commons, Neurology Commons, Pediatrics Commons, Substance Abuse and Addiction Commons