Department of Medicine, Division of Infectious Diseases and Immunology
Immunology and Infectious Disease | Parasitic Diseases | Parasitology
Dendritic cells have an important role in immune surveillance. After being exposed to microbial components, they migrate to secondary lymphoid organs and activate T lymphocytes. Here we show that during mouse malaria, splenic inflammatory monocytes differentiate into monocyte-derived dendritic cells (MO-DCs), which are CD11b+F4/80+CD11c+MHCIIhighDC-SIGNhighLy6c+ and express high levels of CCR5, CXCL9 and CXCL10 (CCR5+CXCL9/10+ MO-DCs). We propose that malaria-induced splenic MO-DCs take a reverse migratory route. After differentiation in the spleen, CCR5+CXCL9/10+ MO-DCs traffic to the brain in a CCR2-independent, CCR5-dependent manner, where they amplify the influx of CD8+ T lymphocytes, leading to a lethal neuropathological syndrome.
Antimicrobial responses, Parasite host response
DOI of Published Version
Nat Commun. 2016 Nov 3;7:13277. doi: 10.1038/ncomms13277. Link to article on publisher's site
Hirako, Isabella C.; Ataide, Marco Antonio; Faustino, Lucas; Assis, Patricia A.; Sorensen, Elizabeth W.; Ueta, Hisashi; Araujo, Natalia M.; Menezes, Gustavo B.; Luster, Andrew D.; and Gazzinelli, Ricardo T., "Splenic differentiation and emergence of CCR5+CXCL9+CXCL10+ monocyte-derived dendritic cells in the brain during cerebral malaria" (2016). Open Access Articles. 2999.
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