Keeping Weight Off: study protocol of an RCT to investigate brain changes associated with mindfulness-based stress reduction
Authors
Fulwiler, Carl E.Siegel, Julia A.
Allison, Jeroan J.
Rosal, Milagros C.
Brewer, Judson A.
King, Jean A.
UMass Chan Affiliations
Prevention Research CenterSchool of Medicine
Department of Quantitative Health Sciences
Department of Medicine, Division of Preventive and Behavioral Medicine
Center for Mindfulness
Department of Psychiatry
Document Type
Journal ArticlePublication Date
2016-11-30Keywords
behavior change maintenancemindfulness
neuroimaging
weight loss
Alternative and Complementary Medicine
Behavior and Behavior Mechanisms
Diagnosis
Investigative Techniques
Metadata
Show full item recordAbstract
INTRODUCTION: Obesity is a growing epidemic fuelled by unhealthy behaviours and associated with significant comorbidities and financial costs. While behavioural interventions produce clinically meaningful weight loss, weight loss maintenance is challenging. This may partially be due to failure to target stress and emotional reactivity. Mindfulness-based stress reduction (MBSR) reduces stress and emotional reactivity and may be a useful tool for behaviour change maintenance. This study seeks to provide a mechanistic understanding for clinical trials of the benefits of MBSR for weight loss maintenance by examining changes in functional connectivity (FC) and the association of these changes with clinical outcomes. METHODS AND ANALYSIS: Community-dwelling individuals (n=80) who intentionally lost > /=5% of their body weight in the past year will be recruited and randomised to an MBSR programme or educational control. FC using resting-state functional MRI will be measured at baseline and 8 weeks. Psychological factors, health behaviours, body mass index and waist circumference will be measured at baseline, 8 weeks and 6 months post intervention. A 12-month telephone follow-up will assess self-reported weight. Analyses will characterise FC changes in response to MBSR in comparison with a control condition, assess the relationship between baseline FC status and pre-post MBSR changes in FC and investigate the association of FC change with changes in psychological factors and weight loss maintenance. ETHICS AND DISSEMINATION: The University of Massachusetts Medical School Institutional Review Board has approved this study, Declaration of Helsinki protocols are being followed, and patients will give written informed consent. The Independent Monitoring Committee will monitor protocol adherence. Results from the study will be disseminated to the medical community at conferences and submitted for publication in peer-reviewed journals when the last patient included has been followed up for 12 months. TRIAL REGISTRATION NUMBER: NCT02189187.Source
BMJ Open. 2016 Nov 30;6(11):e012573. doi: 10.1136/bmjopen-2016-012573. Link to article on publisher's siteDOI
10.1136/bmjopen-2016-012573Permanent Link to this Item
http://hdl.handle.net/20.500.14038/40180PubMed ID
27903561Notes
Co-author Julia Siegel is a medical student at UMass Medical School.
Related Resources
Link to Article in PubMedDistribution License
http://creativecommons.org/licenses/by-nc/4.0/ae974a485f413a2113503eed53cd6c53
10.1136/bmjopen-2016-012573
Scopus Count
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc/4.0/