Gene therapy approaches for the treatment of retinal disorders

UMMS Affiliation

Department of Ophthalmology; Gene Therapy Center; UMass Metabolic Network

Publication Date


Document Type



Eye Diseases | Genetics and Genomics | Ophthalmology


There is an impelling need to develop effective therapeutic strategies for patients with retinal disorders. Gleaning from the large quantity of information gathered over the past two decades on the mechanisms governing degeneration of the retina, it is now possible to devise innovative therapies based on retinal gene transfer. Different gene-based approaches are under active investigation. They include strategies to correct the specific genetic defect in inherited retinal diseases, strategies to delay the onset of blindness independently of the disease-causing mutations, and strategies to reactivate residual cells at late stages of the diseases. In this review, we discuss the status of application of these technologies, outlining the future therapeutic potential for many forms of retinal blinding diseases.


Discov Med. 2016 Oct;22(121):221-229.

Journal/Book/Conference Title

Discovery medicine

Related Resources

Link to Article in PubMed

PubMed ID