Department of Medicine, Division of Cardiovascular Medicine; Department of Quantitative Health Sciences; UMass Metabolic Network
Biological Factors | Genetic Processes | Medical Biochemistry | Nucleic Acids, Nucleotides, and Nucleosides
MicroRNA (miRNA) expression has rapidly grown into one of the largest fields for disease characterization and development of clinical biomarkers. Consensus is lacking in regards to the optimal sample source or if different circulating sources are concordant. Here, using miRNA measurements from contemporaneously obtained whole blood- and plasma-derived RNA from 2391 individuals, we demonstrate that plasma and blood miRNA levels are divergent and may reflect different biological processes and disease associations.
UMCCTS funding, MicroRNAs, Blood plasma, Blood, RNA isolation, Biomarkers, RNA sequencing, Gene expression, Gene regulation
Rights and Permissions
This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
DOI of Published Version
PLoS One. 2016 Apr 28;11(4):e0153691. doi: 10.1371/journal.pone.0153691. eCollection 2016. Link to article on publisher's site
Shah, Ravi; Tanriverdi, Kahraman; Levy, Daniel; Larson, Martin; Gerstein, Mark B.; Mick, Eric O.; Rozowsky, Joel; Kitchen, Robert; Murthy, Venkatesh; Mikalev, Ekaterina; and Freedman, Jane E., "Discordant Expression of Circulating microRNA from Cellular and Extracellular Sources" (2016). Open Access Articles. 2908.
Creative Commons License
This work is licensed under a Creative Commons 1.0 Public Domain Dedication.