UMMS Affiliation
Center for Mindfulness
Publication Date
2016-09-01
Document Type
Article
Disciplines
Behavior and Behavior Mechanisms | Nervous System Diseases | Neuroscience and Neurobiology | Pathological Conditions, Signs and Symptoms | Psychiatry
Abstract
In recent years, there has been increasing interest in the potential for alterations to the brain's resting-state networks (RSNs) to explain various kinds of psychopathology. RSNs provide an intriguing new explanatory framework for hallucinations, which can occur in different modalities and population groups, but which remain poorly understood. This collaboration from the International Consortium on Hallucination Research (ICHR) reports on the evidence linking resting-state alterations to auditory hallucinations (AH) and provides a critical appraisal of the methodological approaches used in this area. In the report, we describe findings from resting connectivity fMRI in AH (in schizophrenia and nonclinical individuals) and compare them with findings from neurophysiological research, structural MRI, and research on visual hallucinations (VH). In AH, various studies show resting connectivity differences in left-hemisphere auditory and language regions, as well as atypical interaction of the default mode network and RSNs linked to cognitive control and salience. As the latter are also evident in studies of VH, this points to a domain-general mechanism for hallucinations alongside modality-specific changes to RSNs in different sensory regions. However, we also observed high methodological heterogeneity in the current literature, affecting the ability to make clear comparisons between studies. To address this, we provide some methodological recommendations and options for future research on the resting state and hallucinations.
Keywords
default mode network, fMRI, perception, psychosis, schizophrenia
Rights and Permissions
Copyright © The Author 2016. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI of Published Version
10.1093/schbul/sbw078
Source
Schizophr Bull. 2016 Sep;42(5):1110-23. doi: 10.1093/schbul/sbw078. Epub 2016 Jun 8. Link to article on publisher's site
Journal/Book/Conference Title
Schizophrenia bulletin
Related Resources
PubMed ID
27280452
Repository Citation
Alderson-Day B, Diederen K, Fernyhough C, Ford JM, Horga G, Margulies DS, McCarthy-Jones S, Northoff G, Shine JM, Turner J, van de Ven V, van Lutterveld R, Waters F, Jardri R. (2016). Auditory Hallucinations and the Brain's Resting-State Networks: Findings and Methodological Observations. Open Access Articles. https://doi.org/10.1093/schbul/sbw078. Retrieved from https://escholarship.umassmed.edu/oapubs/2811
Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.
Included in
Behavior and Behavior Mechanisms Commons, Nervous System Diseases Commons, Neuroscience and Neurobiology Commons, Pathological Conditions, Signs and Symptoms Commons, Psychiatry Commons