Department of Microbiology and Physiological Systems
Cell Biology | Developmental Biology | Immunity
B cells are key components of cellular and humoral immunity and, like all lymphocytes, are thought to originate and renew from hematopoietic stem cells (HSCs). However, our recent single-HSC transfer studies demonstrate that adult bone marrow HSCs do not regenerate B-1a, a subset of tissue B cells required for protection against pneumonia, influenza, and other infections. Since B-1a are regenerated by transfers of fetal liver, the question arises as to whether B-1a derive from fetal, but not adult, HSCs. Here we show that, similar to adult HSCs, fetal HSCs selectively fail to regenerate B-1a. We also show that, in humanized mice, human fetal liver regenerates tissue B cells that are phenotypically similar to murine B-1a, raising the question of whether human HSC transplantation, the mainstay of such models, is sufficient to regenerate human B-1a. Thus, our studies overtly challenge the current paradigm that HSCs give rise to all components of the immune system.
Rights and Permissions
Copyright © 2016 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
DOI of Published Version
Stem Cell Reports. 2016 Jan 12;6(1):137-49. doi: 10.1016/j.stemcr.2015.11.011. Epub 2015 Dec 24. Link to article on publisher's site
Stem cell reports
Ghosn EE, Waters J, Phillips M, Yamamoto R, Long BR, Yang Y, Gerstein RM, Stoddart CA, Nakauchi H, Herzenberg LA. (2016). Fetal Hematopoietic Stem Cell Transplantation Fails to Fully Regenerate the B-Lymphocyte Compartment. Open Access Publications by UMMS Authors. https://doi.org/10.1016/j.stemcr.2015.11.011. Retrieved from https://escholarship.umassmed.edu/oapubs/2767
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.